STMN1 (Stathmin 1) Gene
A key regulator of microtubule dynamics and cell cycle progression
Gene Information Card
| Symbol | STMN1 |
|---|---|
| Full Name | Stathmin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.11 |
| NCBI Gene ID | 3925 ncbi.nlm.nih.gov/gene/3925 |
| Ensembl ID | ENSG00000117632 |
| UniProt ID | P16949 |
| OMIM ID | 151442 |
| HGNC ID | 11380 |
| Aliases | OP18, LAP18, PP17, PP19, PR22, SMN |
Description
STMN1 encodes stathmin 1, a cytosolic phosphoprotein that regulates microtubule dynamics by sequestering tubulin dimers and promoting microtubule catastrophe. It is involved in cell cycle progression, signal transduction, and cellular differentiation. Overexpression is observed in various cancers and correlates with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | Overexpression of STMN1 disrupts microtubule stability, promoting proliferation and resistance to chemotherapy. | PMID: 21551233 |
| Breast carcinoma | High STMN1 expression associated with aggressive tumor phenotype and poor survival. | PMID: 24840125 |
| Non-small cell lung cancer | STMN1 upregulation linked to increased metastasis and chemoresistance. | PMID: 26967287 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 28.5 | High |
| Lymph node | 15.2 | Medium |
| Bone marrow | 12.8 | Medium |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 32.1 | Cervical adenocarcinoma; high expression |
| MCF7 | 18.7 | Breast cancer; moderate expression |
| A549 | 22.4 | Lung carcinoma; high expression |
| K562 | 45.6 | Chronic myeloid leukemia; very high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.97C>T (p.Arg33Trp) | Missense | <0.1% | Alters tubulin binding affinity |
| c.148G>A (p.Glu50Lys) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in STMN1.
Gain of Function (GOF)
Overexpression and phosphorylation changes are associated with gain-of-function in cancer.
Dominant Negative (DN)
Not documented for STMN1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04520 – Adherens junction
• hsa04810 – Regulation of actin cytoskeleton
• hsa05200 – Pathways in cancer
• hsa05205 – Proteoglycans in cancer
• hsa05215 – Prostate cancer
Protein Summary
Stathmin 1 (STMN1) is a 149-amino-acid phosphoprotein that acts as a key regulator of microtubule dynamics. It binds tubulin heterodimers, preventing their polymerization and promoting microtubule catastrophe. Phosphorylation by various kinases (e.g., CDKs, PKA, MAPK) inactivates its microtubule-destabilizing activity, allowing cell cycle progression. STMN1 is highly expressed in the brain and in many cancers, where it contributes to proliferation, invasion, and drug resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STMN1 Knockout HEK293 Cell Line | EDJ-KQ757 | Human | 3925 | Details Get a Quote |
| STMN1 Knockout A-549 Cell Line | EDJ-KQ19423 | Human | 3925 | Details Get a Quote |
| STMN1 Knockout HCT 116 Cell Line | EDJ-KQ19424 | Human | 3925 | Details Get a Quote |
| STMN1 Knockout HeLa Cell Line | EDJ-KQ19425 | Human | 3925 | Details Get a Quote |
