STK38 (Serine/Threonine Kinase 38)
A member of the NDR (Nuclear Dbf2-Related) kinase family involved in cell cycle regulation, apoptosis, and Hippo signaling pathway.
Gene Information Card
| Symbol | STK38 |
|---|---|
| Full Name | Serine/Threonine Kinase 38 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 11329 ncbi.nlm.nih.gov/gene/11329 |
| Ensembl ID | ENSG00000112208 |
| UniProt ID | Q15208 |
| OMIM ID | 606964 |
| HGNC ID | 11403 |
| Aliases | NDR1, NDR, STK38L |
Description
STK38 (Serine/Threonine Kinase 38), also known as NDR1, is a member of the NDR (Nuclear Dbf2-Related) kinase subfamily within the AGC kinase group. It plays critical roles in cell cycle progression, centrosome duplication, apoptosis, and the Hippo signaling pathway. STK38 is activated by MST1/MST2 kinases and MOB1 co-activators, and its dysregulation is implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of STK38 affects Hippo pathway-mediated cell proliferation and apoptosis; altered expression linked to tumorigenesis. | COSMIC; literature review |
| Neurodevelopmental disorders | Mutations in STK38 may impair neuronal cell cycle control and survival. | ClinVar; limited case reports |
| Immune system disorders | STK38 involvement in T-cell apoptosis and immune regulation. | UniProt; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Spleen | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells; moderate expression |
| HeLa | 8.9 | Cervical cancer cells; low expression |
| A549 | 7.5 | Lung carcinoma; low expression |
| MCF7 | 6.8 | Breast cancer; low expression |
| K562 | 11.1 | Leukemia cells; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Potential loss of kinase activity; reported in COSMIC |
| c.487G>A (p.Gly163Arg) | Missense | <0.1% | Unknown functional impact; rare variant |
| c.1123A>G (p.Asn375Asp) | Missense | <0.1% | Reported in cancer samples; possible gain-of-function |
Mutation functional classification
Loss of Function (LOF)
p.Thr34Met may reduce kinase activity; further validation needed.
Gain of Function (GOF)
p.Asn375Asp suspected in cancer; not confirmed.
Dominant Negative (DN)
No dominant-negative mutations reported for STK38.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 (protein kinase activity) | • GO:0005524 (ATP binding) |
| • GO:0006468 (protein phosphorylation) | • GO:0007049 (cell cycle) |
| • GO:0006915 (apoptotic process) | • GO:0035556 (intracellular signal transduction) |
| • GO:0035329 (Hippo signaling) |
Pathways
• Hippo signaling pathway (Reactome: R-HSA-2028269)
• Signaling by MST1/MST2 (Reactome: R-HSA-2028269)
• Cell Cycle
• Mitotic (Reactome: R-HSA-69278)
Protein Summary
STK38 encodes a 465-amino acid serine/threonine kinase (NDR1) with an N-terminal regulatory domain, a catalytic kinase domain, and a C-terminal extension. It is activated by phosphorylation at Thr444 and Ser281 via MST1/2 and MOB1. STK38 regulates centrosome duplication, mitotic exit, and apoptosis. It is ubiquitously expressed with highest levels in brain and testis. Mutations are rare but may contribute to cancer and developmental phenotypes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK38L Knockout HEK293 Cell Line | EDJ-KQ3112 | Human | 23012 | Details Get a Quote |
| STK38 Knockout HEK293 Cell Line | EDJ-KQ7373 | Human | 11329 | Details Get a Quote |
| STK38 Knockout HeLa Cell Line | EDJ-KQ31126 | Human | 11329 | Details Get a Quote |
| STK38L Knockout A-549 Cell Line | EDJ-KQ24452 | Human | 23012 | Details Get a Quote |
| STK38L Knockout HCT 116 Cell Line | EDJ-KQ24453 | Human | 23012 | Details Get a Quote |
| STK38L Knockout HeLa Cell Line | EDJ-KQ24454 | Human | 23012 | Details Get a Quote |
| STK38 Knockout A-549 Cell Line | EDJ-KQ32493 | Human | 11329 | Details Get a Quote |
| STK38 Knockout HCT 116 Cell Line | EDJ-KQ32494 | Human | 11329 | Details Get a Quote |
| STK38L Knockout HAP1 Cell Line | EDC07901 | Human | 23012 | Details Get a Quote |
| STK38 Knockout HAP1 Cell Line | EDC07804 | Human | 11329 | Details Get a Quote |
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