STK26 (Serine/Threonine Kinase 26)
MST4, a STE20-like kinase involved in cell growth, apoptosis, and cancer signaling
Gene Information Card
| Symbol | STK26 |
|---|---|
| Full Name | Serine/Threonine Kinase 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 51765 ncbi.nlm.nih.gov/gene/51765 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9P289 |
| OMIM ID | 609474 |
| HGNC ID | 11413 |
| Aliases | MST4, MASK, STE20-like kinase MST4 |
Description
STK26 (serine/threonine kinase 26), also known as MST4, encodes a member of the STE20-like kinase family. The protein activates MAPK signaling pathways, regulates cell proliferation, apoptosis, and cytoskeletal organization. It is implicated in several cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and migration via ERK signaling | COSMIC, PMID: 25605249 |
| Prostate cancer | MST4 knockdown reduces tumor growth in xenograft models | PMID: 23966114 |
| Gastric cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27323850 |
| Hepatocellular carcinoma | MST4 activates YAP/TAZ to drive oncogenesis | PMID: 26051942 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Brain | 6.1 | Low |
| Lung | 10.7 | Medium |
| Breast | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.0 | Cervical cancer cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| HepG2 | 9.8 | Hepatocellular carcinoma cell line |
| A549 | 13.5 | Lung cancer cell line |
| PC3 | 16.1 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown functional effect |
| c.472G>A (p.Glu158Lys) | Missense | <0.1% | Predicted damaging (SIFT) |
| c.788_789insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the kinase domain, reducing catalytic activity.
Gain of Function (GOF)
Missense mutations in the activation loop may enhance kinase activity, though evidence is limited.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• Hippo signaling pathway (KEGG: hsa04390)
• Apoptosis (KEGG: hsa04210)
Protein Summary
STK26 (MST4) is a 431-amino-acid serine/threonine kinase with an N-terminal catalytic domain and a C-terminal regulatory region. It phosphorylates downstream targets such as ERK, YAP, and TAZ, modulating cell growth and survival. The protein is widely expressed and its dysregulation contributes to tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK26 Knockout HEK293 Cell Line | EDJ-KQ11218 | Human | 51765 | Details Get a Quote |
| STK26 Knockout A-549 Cell Line | EDJ-KQ39284 | Human | 51765 | Details Get a Quote |
| STK26 Knockout HCT 116 Cell Line | EDJ-KQ39285 | Human | 51765 | Details Get a Quote |
| STK26 Knockout HeLa Cell Line | EDJ-KQ39286 | Human | 51765 | Details Get a Quote |
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