STK25: Serine/Threonine Kinase 25
A member of the STE20 kinase family involved in cell polarity, migration, and stress response
Gene Information Card
| Symbol | STK25 |
|---|---|
| Full Name | Serine/Threonine Kinase 25 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 10494 ncbi.nlm.nih.gov/gene/10494 |
| Ensembl ID | ENSG00000115641 |
| UniProt ID | O00506 |
| OMIM ID | 602255 |
| HGNC ID | 11403 |
| Aliases | YSK1, SOK1, STE20/SPS1-related proline-alanine-rich kinase |
Description
STK25 (Serine/Threonine Kinase 25) encodes a member of the STE20 family of serine/threonine kinases. The protein is involved in regulating cell polarity, cell migration, and stress-activated signaling pathways. It interacts with the Golgi matrix protein GM130 and plays a role in the Hippo signaling pathway. STK25 is implicated in cancer progression, neurodegenerative diseases, and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | STK25 overexpression promotes cell migration and invasion via activation of ERK and JNK pathways | PMID: 25695633 |
| Breast cancer | STK25 regulates cell polarity and migration; altered expression correlates with poor prognosis | PMID: 27322070 |
| Alzheimer's disease | STK25 interacts with tau and modulates tau phosphorylation | PMID: 21930797 |
| Type 2 diabetes | STK25 deficiency improves insulin sensitivity and glucose tolerance in mice | PMID: 25249562 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Heart | 6.7 | Low |
| Lung | 9.1 | Low |
| Pancreas | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.8 | Hepatocellular carcinoma cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| SH-SY5Y | 18.5 | Neuroblastoma cell line |
| HEK293 | 9.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511C>T (p.Arg171Trp) | Missense | <0.01% | Reduced kinase activity in vitro |
| c.874G>A (p.Glu292Lys) | Missense | <0.01% | Unknown functional effect |
| c.1234_1235insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions and nonsense mutations are predicted to cause loss of kinase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No dominant-negative mutations described in literature or curated sources.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 - protein kinase activity | • GO:0004674 - protein serine/threonine kinase activity |
| • GO:0005524 - ATP binding | • GO:0006468 - protein phosphorylation |
| • GO:0030036 - actin cytoskeleton organization | • GO:0035556 - intracellular signal transduction |
| • GO:0040011 - locomotion | • GO:0090263 - positive regulation of canonical Wnt signaling pathway |
Pathways
• Hippo signaling pathway (Reactome: R-HSA-2028269)
• STE20 kinase signaling (Reactome: R-HSA-5628897)
• Stress-activated MAPK cascade (Reactome: R-HSA-450294)
Protein Summary
STK25 is a 426-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory region. It localizes to the Golgi apparatus and centrosomes, where it regulates cell polarity and migration. The kinase is activated by oxidative stress and osmotic shock. STK25 phosphorylates multiple substrates including MOB1, a core component of the Hippo pathway. Its expression is altered in several cancers and neurodegenerative conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK25 Knockout HEK293 Cell Line | EDJ-KQ7062 | Human | 10494 | Details Get a Quote |
| STK25 Knockout A-549 Cell Line | EDJ-KQ31871 | Human | 10494 | Details Get a Quote |
| STK25 Knockout HCT 116 Cell Line | EDJ-KQ31872 | Human | 10494 | Details Get a Quote |
| STK25 Knockout HeLa Cell Line | EDJ-KQ31873 | Human | 10494 | Details Get a Quote |
| STK25 Knockout HAP1 Cell Line | EDC07937 | Human | 10494 | Details Get a Quote |
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