STK24: Serine/Threonine Kinase 24
A key regulator of cell migration, apoptosis, and neuronal development, implicated in cancer and neurological disorders.
Gene Information Card
| Symbol | STK24 |
|---|---|
| Full Name | Serine/Threonine Kinase 24 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q32.2 |
| NCBI Gene ID | 8428 ncbi.nlm.nih.gov/gene/8428 |
| Ensembl ID | ENSG00000102572 |
| UniProt ID | Q9Y6E0 |
| OMIM ID | 604984 |
| HGNC ID | 11403 |
| Aliases | MST3, STK3, STE20-like kinase MST3 |
Description
STK24 (Serine/Threonine Kinase 24), also known as MST3, is a member of the STE20 family of kinases. It plays a critical role in regulating cell migration, apoptosis, and cytoskeletal dynamics. STK24 is involved in the Hippo signaling pathway and has been implicated in cancer progression and neurodevelopmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of STK24 expression and activity alters cell migration and apoptosis, promoting tumorigenesis and metastasis. | COSMIC; NCBI Gene |
| Neurodevelopmental disorders | STK24 mutations affect neuronal migration and brain development, potentially contributing to intellectual disability. | OMIM; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 10.8 | Medium |
| Liver | 8.5 | Low |
| Kidney | 12.1 | Medium |
| Heart | 9.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.5 | High expression in embryonic kidney cells |
| HeLa | 11.2 | Moderate expression in cervical cancer cells |
| SH-SY5Y | 16.8 | High expression in neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511G>A (p.Gly171Arg) | Missense | <0.1% | Alters kinase activity; associated with neurodevelopmental phenotypes |
| c.1003C>T (p.Arg335Trp) | Missense | <0.1% | Potential loss of function; reported in cancer samples |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain (e.g., p.Gly171Arg) reduce catalytic activity, impairing downstream signaling.
Gain of Function (GOF)
Not well documented; overexpression in some cancers may lead to increased cell migration.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • apoptotic process | • cell migration |
| • cytoskeleton organization | • Hippo signaling |
Pathways
• Hippo signaling pathway
• Apoptosis
• Regulation of actin cytoskeleton
Protein Summary
STK24 encodes a 431-amino acid serine/threonine kinase (MST3) with an N-terminal kinase domain and a C-terminal regulatory domain. It phosphorylates substrates involved in cell polarity, migration, and survival. The protein is widely expressed, with highest levels in brain and kidney. STK24 is activated by autophosphorylation and can be cleaved by caspases during apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK24 Knockout HEK293 Cell Line | EDJ-KQ6238 | Human | 8428 | Details Get a Quote |
| STK24 Knockout A-549 Cell Line | EDJ-KQ30087 | Human | 8428 | Details Get a Quote |
| STK24 Knockout HCT 116 Cell Line | EDJ-KQ30088 | Human | 8428 | Details Get a Quote |
| STK24 Knockout HeLa Cell Line | EDJ-KQ30089 | Human | 8428 | Details Get a Quote |
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