STK11IP
Serine/Threonine Kinase 11 Interacting Protein
Gene Information Card
| Symbol | STK11IP |
|---|---|
| Full Name | Serine/Threonine Kinase 11 Interacting Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 114790 ncbi.nlm.nih.gov/gene/114790 |
| Ensembl ID | ENSG00000144381 |
| UniProt ID | Q8N1F8 |
| OMIM ID | 607172 |
| HGNC ID | 114790 |
| Aliases | LKB1IP, LKB1-interacting protein 1, FLJ11273 |
Description
STK11IP encodes a protein that interacts with serine/threonine kinase 11 (STK11, also known as LKB1). This interaction is involved in cellular processes such as cell polarity, energy metabolism, and tumor suppression. The gene is located on chromosome 2q35 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Peutz-Jeghers syndrome (PJS) | STK11IP interacts with STK11; mutations in STK11 cause PJS, but STK11IP variants may modify disease risk or severity. | ClinVar, OMIM |
| Non-small cell lung cancer | Altered STK11IP expression or interaction with STK11 may contribute to tumorigenesis. | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| A549 | 7.5 | Moderate expression |
| HepG2 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons and truncated protein.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • kinase binding |
| • cytoplasm | • nucleus |
Pathways
• LKB1 signaling pathway
• AMPK signaling
Protein Summary
The STK11IP protein is a 1,200-amino acid polypeptide that interacts with STK11/LKB1. It is involved in regulating cell polarity and energy homeostasis. The protein is localized in the cytoplasm and nucleus and is expressed in various tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK11IP Knockout HEK293 Cell Line | EDJ-KQ7462 | Human | 114790 | Details Get a Quote |
| STK11IP Knockout A-549 Cell Line | EDJ-KQ32679 | Human | 114790 | Details Get a Quote |
| STK11IP Knockout HCT 116 Cell Line | EDJ-KQ32680 | Human | 114790 | Details Get a Quote |
| STK11IP Knockout HeLa Cell Line | EDJ-KQ32681 | Human | 114790 | Details Get a Quote |
