STK10: Serine/Threonine Kinase 10
A key regulator of lymphocyte migration and immune response
Gene Information Card
| Symbol | STK10 |
|---|---|
| Full Name | Serine/Threonine Kinase 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.1 |
| NCBI Gene ID | 6793 ncbi.nlm.nih.gov/gene/6793 |
| Ensembl ID | ENSG00000113520 |
| UniProt ID | O94804 |
| OMIM ID | 603919 |
| HGNC ID | 11388 |
| Aliases | LOK, PRO2730 |
Description
STK10 (Serine/Threonine Kinase 10) encodes a member of the STE20-like kinase family. The protein is involved in regulating lymphocyte migration, cell polarity, and cytoskeletal reorganization. It phosphorylates and activates downstream targets such as p21-activated kinases (PAKs) and plays a role in immune cell trafficking and T-cell activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | STK10 overexpression may promote tumor cell migration and invasion via PAK signaling | COSMIC; PMID: 23542345 |
| Colorectal cancer | STK10 mutations and altered expression linked to poor prognosis | COSMIC; PMID: 25691885 |
| Lung cancer | STK10 copy number gains and increased expression observed in non-small cell lung cancer | COSMIC; PMID: 27060138 |
| Melanoma | STK10 mutations identified in metastatic melanoma samples | COSMIC; PMID: 25740735 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Thymus | 7.9 | Low |
| Lung | 6.1 | Low |
| Colon | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression in embryonic kidney cells |
| Jurkat | 22.1 | T-cell line; high expression |
| HeLa | 9.8 | Cervical cancer cell line; moderate expression |
| A549 | 7.3 | Lung cancer cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1243G>A (p.Glu415Lys) | Missense | 0.2% | Potential loss of kinase activity |
| c.1876C>T (p.Arg626Trp) | Missense | 0.1% | Unknown functional impact |
| c.2122_2123insA (p.Thr708Asnfs*5) | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in STK10 are predicted to truncate the kinase domain, impairing catalytic activity and downstream signaling.
Gain of Function (GOF)
No well-characterized gain-of-function mutations have been reported for STK10.
Dominant Negative (DN)
No dominant-negative mutations have been described for STK10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PAK signaling pathway
• Regulation of actin cytoskeleton
• T-cell receptor signaling pathway
Protein Summary
STK10 (LOK) is a 968-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory region. It localizes to the cytoplasm and is enriched in lymphoid tissues. STK10 phosphorylates PAK1 and PAK2, regulating cell polarity, adhesion, and migration. It is essential for proper lymphocyte homing and immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK10 Knockout HEK293 Cell Line | EDJ-KQ2220 | Human | 6793 | Details Get a Quote |
| STK10 Knockout A-549 Cell Line | EDJ-KQ22491 | Human | 6793 | Details Get a Quote |
| STK10 Knockout HCT 116 Cell Line | EDJ-KQ22492 | Human | 6793 | Details Get a Quote |
| STK10 Knockout HeLa Cell Line | EDJ-KQ22493 | Human | 6793 | Details Get a Quote |
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