ST3GAL2: ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2
A key enzyme in sialic acid transfer, involved in glycoprotein and glycolipid biosynthesis, with implications in cancer and immune function.
Gene Information Card
| Symbol | ST3GAL2 |
|---|---|
| Full Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q22.1 |
| NCBI Gene ID | 6483 ncbi.nlm.nih.gov/gene/6483 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | Q16842 |
| OMIM ID | 604034 |
| HGNC ID | 10863 |
| Aliases | SIAT4B, ST3GalII, ST3GALII |
Description
ST3GAL2 encodes a Golgi membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates via an alpha-2,3 linkage. This enzyme is involved in the biosynthesis of sialylated glycoproteins and glycolipids, which are critical for cell-cell interactions, immune recognition, and tumor progression. The gene is expressed in multiple tissues, with highest levels in brain, placenta, and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered sialylation of cell surface glycans promotes metastasis and immune evasion. ST3GAL2 overexpression is associated with poor prognosis. | PMID: 25605274, COSMIC |
| Breast Cancer | Increased ST3GAL2 expression correlates with tumor grade and lymph node metastasis. | PMID: 23542377 |
| Gastric Cancer | Upregulation of ST3GAL2 enhances cell migration and invasion via altered glycosylation. | PMID: 27323861 |
| Hepatocellular Carcinoma | ST3GAL2-mediated sialylation of beta1-integrin promotes cell adhesion and migration. | PMID: 28411363 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Placenta | 10.2 | High |
| Testis | 9.8 | High |
| Lung | 6.1 | Medium |
| Colon | 5.3 | Medium |
| Breast | 4.7 | Medium |
| Liver | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.4 | High expression in embryonic kidney cells |
| HeLa | 6.2 | Moderate expression in cervical cancer cells |
| MCF7 | 5.9 | Moderate expression in breast cancer cells |
| HCT116 | 7.1 | High expression in colorectal cancer cells |
| A549 | 4.3 | Low-moderate expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104G>A (p.Arg35His) | Missense | <0.01% | Unknown functional impact; rare population variant |
| c.511C>T (p.Arg171Trp) | Missense | <0.01% | Predicted damaging by SIFT; potential loss of activity |
| c.832G>A (p.Gly278Ser) | Missense | <0.01% | Located in catalytic domain; may reduce enzyme activity |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg171Trp, p.Gly278Ser) are predicted to reduce sialyltransferase activity, potentially altering glycan profiles.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in literature or databases.
Dominant Negative (DN)
No evidence for dominant-negative effects; ST3GAL2 functions as a monomer.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Glycosphingolipid biosynthesis - lacto and neolacto series (KEGG: hsa00601)
• N-Glycan biosynthesis (KEGG: hsa00510)
• Sialic acid metabolism (Reactome: R-HSA-4085001)
Protein Summary
ST3GAL2 is a type II transmembrane protein localized to the Golgi apparatus. It catalyzes the transfer of sialic acid to terminal galactose residues on glycoproteins and glycolipids, forming alpha-2,3 linkages. The protein contains a short N-terminal cytoplasmic tail, a transmembrane domain, and a large C-terminal catalytic domain facing the Golgi lumen. Its activity is essential for the synthesis of sialyl Lewis antigens and other sialylated structures involved in cell adhesion and signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ST3GAL2 Knockout HEK293 Cell Line | EDJ-KQ5751 | Human | 6483 | Details Get a Quote |
| ST3GAL2 Knockout A-549 Cell Line | EDJ-KQ29163 | Human | 6483 | Details Get a Quote |
| ST3GAL2 Knockout HCT 116 Cell Line | EDJ-KQ29164 | Human | 6483 | Details Get a Quote |
| ST3GAL2 Knockout HeLa Cell Line | EDJ-KQ29165 | Human | 6483 | Details Get a Quote |
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