SRXN1 Gene - Sulfiredoxin 1
Key regulator of oxidative stress response and redox homeostasis
Gene Information Card
| Symbol | SRXN1 |
|---|---|
| Full Name | Sulfiredoxin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | 140809 ncbi.nlm.nih.gov/gene/140809 |
| Ensembl ID | ENSG00000101333 |
| UniProt ID | Q9BYN0 |
| OMIM ID | 618853 |
| HGNC ID | 26763 |
| Aliases | SRX, NPNT, FLJ21080 |
Description
SRXN1 encodes sulfiredoxin 1, an antioxidant enzyme that specifically reduces overoxidized peroxiredoxins (PRDX1, PRDX2, PRDX3, PRDX4) via a unique ATP-dependent mechanism. It plays a critical role in restoring peroxidase activity after oxidative stress, thereby regulating cellular redox signaling and protecting against oxidative damage. SRXN1 is induced under stress conditions and is implicated in cancer, neurodegenerative diseases, and aging.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | SRXN1 overexpression promotes tumor cell survival by reducing oxidative stress and enhancing resistance to chemotherapy. | COSMIC; PMID: 23431136 |
| Neurodegenerative disorders | Dysregulation of SRXN1 contributes to oxidative damage in neurons, linked to Parkinson's and Alzheimer's disease. | ClinVar; PMID: 25664854 |
| Atherosclerosis | SRXN1 modulates vascular oxidative stress and inflammation, affecting plaque formation. | NCBI Gene; PMID: 21930790 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 9.8 | Medium |
| Heart | 6.2 | Low |
| Brain | 4.1 | Low |
| Lung | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma cell line |
| HEK293 | 8.7 | Embryonic kidney cells |
| SH-SY5Y | 5.4 | Neuroblastoma cell line |
| A549 | 4.2 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.217C>T (p.Arg73Cys) | Missense | <0.01% | Reduced catalytic activity; associated with oxidative stress sensitivity |
| c.344G>A (p.Arg115Gln) | Missense | <0.01% | Unknown functional impact |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Arg73Cys) impair sulfiredoxin activity, reducing peroxiredoxin regeneration and increasing oxidative damage.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • antioxidant activity (GO:0016209) | • cell redox homeostasis (GO:0045454) |
| • cellular response to oxidative stress (GO:0034599) | • protein binding (GO:0005515) |
| • hydrolase activity (GO:0016787) |
Pathways
• Peroxiredoxin regeneration pathway
• Oxidative stress response pathway
• NF-kB signaling pathway
Protein Summary
Sulfiredoxin 1 is a 137-amino acid protein (15.6 kDa) localized in the cytoplasm and mitochondria. It catalyzes the ATP-dependent reduction of cysteine-sulfinic acid (Cys-SO2H) in peroxiredoxins, restoring their peroxidase function. The protein contains a conserved Cys-99 active site and is induced by NRF2 transcription factor under oxidative stress. Post-translational modifications include phosphorylation and oxidation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRXN1 Knockout HEK293 Cell Line | EDJ-KQ9816 | Human | 140809 | Details Get a Quote |
| SRXN1 Knockout A-549 Cell Line | EDJ-KQ35455 | Human | 140809 | Details Get a Quote |
| SRXN1 Knockout HCT 116 Cell Line | EDJ-KQ36664 | Human | 140809 | Details Get a Quote |
| SRXN1 Knockout HeLa Cell Line | EDJ-KQ36665 | Human | 140809 | Details Get a Quote |
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