SLK (STE20 Like Kinase)
A serine/threonine kinase involved in cell migration, cytoskeletal reorganization, and apoptosis.
Gene Information Card
| Symbol | SLK |
|---|---|
| Full Name | STE20 Like Kinase |
| Gene Type | Protein coding |
| Chromosomal Location | 10q25.1 |
| NCBI Gene ID | 9748 ncbi.nlm.nih.gov/gene/9748 |
| Ensembl ID | ENSG00000165655 |
| UniProt ID | Q9H2G2 |
| OMIM ID | 608479 |
| HGNC ID | 11088 |
| Aliases | STK2, KIAA0204, LOSK, bA16H23.1 |
Description
SLK (STE20 Like Kinase) is a protein-coding gene that encodes a serine/threonine kinase belonging to the STE20 family. The protein is involved in the regulation of cell migration, cytoskeletal dynamics, and apoptosis. It acts as a downstream effector of Rho family GTPases and plays a role in stress fiber formation and focal adhesion turnover. SLK is widely expressed in various tissues and has been implicated in cancer progression and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of SLK promotes cell migration and invasion through cytoskeletal remodeling. | NCBI Gene, PubMed |
| Prostate cancer | SLK expression correlates with tumor aggressiveness and metastasis. | NCBI Gene, PubMed |
| Neurodegenerative diseases | SLK-mediated phosphorylation of tau and other cytoskeletal proteins may contribute to pathology. | UniProt, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 45.2 | High |
| Spleen | 38.1 | High |
| Lung | 25.3 | Medium |
| Brain | 18.7 | Medium |
| Liver | 12.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 30.5 | Cervical cancer cell line |
| MCF7 | 22.8 | Breast cancer cell line |
| A549 | 19.2 | Lung cancer cell line |
| HEK293 | 15.6 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% | Unknown functional impact |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
| c.890A>G (p.Glu297Gly) | Missense | <0.01% | Altered kinase activity |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to result in truncated or absent protein, leading to loss of kinase activity.
Gain of Function (GOF)
Missense mutations in the kinase domain may enhance catalytic activity, potentially promoting oncogenic signaling.
Dominant Negative (DN)
No dominant negative mutations have been reported for SLK.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Rho GTPase signaling
• Apoptosis signaling
• Cytoskeletal regulation by Rho GTPases
Protein Summary
The SLK protein is a 1235-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory region. It localizes to focal adhesions and the actin cytoskeleton, where it phosphorylates substrates involved in cell adhesion and migration. SLK is activated by autophosphorylation and by upstream signals from Rho family GTPases. Its expression is regulated during cell cycle and stress conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLK Knockout HEK293 Cell Line | EDJ-KQ1221 | Human | 9748 | Details Get a Quote |
| SLK Knockout A-549 Cell Line | EDJ-KQ21846 | Human | 9748 | Details Get a Quote |
| SLK Knockout HCT 116 Cell Line | EDJ-KQ21848 | Human | 9748 | Details Get a Quote |
| SLK Knockout HeLa Cell Line | EDJ-KQ21849 | Human | 9748 | Details Get a Quote |
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