SLCO3A1: Solute Carrier Organic Anion Transporter Family Member 3A1
Organic anion transporting polypeptide 3A1 (OATP3A1) gene - function, expression, and disease associations
Gene Information Card
| Symbol | SLCO3A1 |
|---|---|
| Full Name | Solute carrier organic anion transporter family member 3A1 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q26.1 |
| NCBI Gene ID | 28232 ncbi.nlm.nih.gov/gene/28232 |
| Ensembl ID | ENSG00000137869 |
| UniProt ID | Q9UIG8 |
| OMIM ID | 612435 |
| HGNC ID | 10962 |
| Aliases | OATP3A1, OATP-D, OATP3A1_v1, SLC21A11 |
Description
SLCO3A1 encodes a member of the organic anion transporting polypeptide (OATP) family, specifically OATP3A1. This transmembrane protein mediates the sodium-independent transport of organic anions, including bile acids, steroid conjugates, and various drugs. It is widely expressed in multiple tissues, with highest levels in testis, brain, and kidney. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression of SLCO3A1 may affect androgen and steroid conjugate transport, influencing tumor growth | Expression studies in tumor tissues (PMID: 21516111) |
| Colorectal cancer | Dysregulation of OATP transporters including SLCO3A1 implicated in drug resistance and metabolic reprogramming | Gene expression profiling (PMID: 23455423) |
| Hepatocellular carcinoma | Reduced expression of SLCO3A1 may alter bile acid homeostasis and promote carcinogenesis | Tissue microarray analysis (PMID: 25652263) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Brain | 8.3 | Medium |
| Kidney | 7.1 | Medium |
| Liver | 4.2 | Low |
| Lung | 3.8 | Low |
| Heart | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression in recombinant systems |
| HepG2 | 6.8 | Moderate endogenous expression |
| MCF7 | 4.5 | Low expression |
| A549 | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1246G>A (p.Gly416Ser) | Missense | <0.01% | Unknown functional effect |
| c.1738C>T (p.Arg580Trp) | Missense | <0.01% | Unknown functional effect |
| c.2114A>G (p.Asn705Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for SLCO3A1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • organic anion transmembrane transporter activity (GO:0008514) | • bile acid transmembrane transporter activity (GO:0015125) |
| • symporter activity (GO:0015293) | • integral component of membrane (GO:0016021) |
| • transmembrane transport (GO:0055085) |
Pathways
• Transport of organic anions (Reactome: R-HSA-879518)
• Bile acid and bile salt metabolism (Reactome: R-HSA-194068)
Protein Summary
OATP3A1 is a 710-amino acid transmembrane protein with 12 predicted transmembrane domains. It functions as a sodium-independent organic anion transporter, facilitating the cellular uptake of various endogenous compounds (e.g., bile acids, steroid conjugates, thyroid hormones) and xenobiotics. The protein is glycosylated and localized to the plasma membrane. Alternative splicing produces variants with different substrate specificities.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLCO3A1 Knockout HEK293 Cell Line | EDJ-KQ8848 | Human | 28232 | Details Get a Quote |
| SLCO3A1 Knockout A-549 Cell Line | EDJ-KQ33918 | Human | 28232 | Details Get a Quote |
| SLCO3A1 Knockout HCT 116 Cell Line | EDJ-KQ35162 | Human | 28232 | Details Get a Quote |
| SLCO3A1 Knockout HeLa Cell Line | EDJ-KQ35163 | Human | 28232 | Details Get a Quote |
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