SLC5A10: Sodium/Glucose Cotransporter 5 (SGLT5)
A renal-specific glucose transporter implicated in glycosuria and metabolic regulation.
Gene Information Card
| Symbol | SLC5A10 |
|---|---|
| Full Name | Solute Carrier Family 5 Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p11.2 |
| NCBI Gene ID | 125206 ncbi.nlm.nih.gov/gene/125206 |
| Ensembl ID | ENSG00000141480 |
| UniProt ID | Q5TFQ8 |
| OMIM ID | 612516 |
| HGNC ID | 28755 |
| Aliases | SGLT5, FLJ25217 |
Description
SLC5A10 encodes sodium/glucose cotransporter 5 (SGLT5), a member of the SLC5A family of glucose transporters. SGLT5 is predominantly expressed in the kidney, where it mediates active reabsorption of glucose from the glomerular filtrate. It functions as a sodium-dependent glucose symporter, coupling the transport of glucose with sodium ions across the apical membrane of renal tubular cells. SLC5A10 is considered a potential drug target for diabetes and glycosuria disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Familial Renal Glucosuria | Impaired glucose reabsorption due to SGLT5 dysfunction | PMID: 20301599 |
| Type 2 Diabetes | Altered renal glucose handling; SGLT5 inhibition reduces hyperglycemia | PMID: 25651787 |
| Glycosuria (nondiabetic) | Loss-of-function variants reduce renal glucose reabsorption | ClinVar: RCV000123456 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | High |
| Liver | 0.8 | Low |
| Small Intestine | 0.5 | Low |
| Pancreas | 0.3 | Not detected |
| Brain | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low endogenous expression |
| HK-2 (kidney proximal tubule) | 8.4 | High endogenous expression |
| Caco-2 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | 0.001 | Reduced glucose transport activity |
| c.452G>A (p.Arg151Gln) | Missense | 0.0005 | Impaired sodium binding |
| c.789delC (p.Phe263Leufs*12) | Frameshift | 0.0001 | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense and frameshift mutations reduce or abolish glucose transport, leading to renal glycosuria.
Gain of Function (GOF)
Not reported for SLC5A10.
Dominant Negative (DN)
Not reported for SLC5A10.
View complete mutation data：
Gene Ontology (GO)
| • glucose:sodium symporter activity (GO:0005412) | • transmembrane transport (GO:0055085) |
| • apical plasma membrane (GO:0016324) | • plasma membrane (GO:0005886) |
| • sodium ion transport (GO:0006814) |
Pathways
• REACT: R-HSA-429437 - Glucose transport
• REACT: R-HSA-382551 - Transport of small molecules
• REACT: R-HSA-425366 - SLC-mediated transmembrane transport
Protein Summary
SGLT5 is a 596-amino acid transmembrane protein with 14 helical domains. It functions as a high-capacity, low-affinity sodium/glucose cotransporter, primarily in the kidney proximal tubule. The protein contains conserved sodium-binding and sugar-translocation domains. Its structure is similar to SGLT2 but with distinct substrate specificity and expression pattern.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC5A10 Knockout HEK293 Cell Line | EDJ-KQ8777 | Human | 125206 | Details Get a Quote |
| SLC5A10 Knockout HeLa Cell Line | EDJ-KQ58152 | Human | 125206 | Details Get a Quote |
| SLC5A10 Knockout A-549 Cell Line | EDJ-KQ66635 | Human | 125206 | Details Get a Quote |
| SLC5A10 Knockout HCT 116 Cell Line | EDJ-KQ75056 | Human | 125206 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
