SLC38A7: Solute Carrier Family 38 Member 7
A glutamine transporter with roles in amino acid homeostasis and cancer metabolism
Gene Information Card
| Symbol | SLC38A7 |
|---|---|
| Full Name | Solute Carrier Family 38 Member 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 55238 ncbi.nlm.nih.gov/gene/55238 |
| Ensembl ID | ENSG00000102974 |
| UniProt ID | Q9NVC3 |
| OMIM ID | 616525 |
| HGNC ID | 29515 |
| Aliases | SNAT7, FLJ20489 |
Description
SLC38A7 (Solute Carrier Family 38 Member 7), also known as SNAT7, encodes a sodium-coupled neutral amino acid transporter that mediates the uptake of glutamine, alanine, asparagine, and histidine. It is a member of the SLC38 family of amino acid transporters and is involved in cellular amino acid homeostasis, mTOR signaling, and nitrogen metabolism. SLC38A7 is widely expressed and has been implicated in cancer cell proliferation and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Upregulation of SLC38A7 supports glutamine uptake to fuel anabolic metabolism and mTORC1 activation in tumor cells. | COSMIC; literature (e.g., PMID: 28431213) |
| Colorectal cancer | SLC38A7 overexpression correlates with poor prognosis and increased glutamine dependence. | COSMIC; TCGA data |
| Hepatocellular carcinoma | SLC38A7 promotes glutamine uptake and cell proliferation; knockdown reduces tumor growth. | Literature (PMID: 31570863) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 9.8 | Medium |
| Kidney | 8.2 | Medium |
| Lung | 6.4 | Low |
| Colon | 7.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | High expression |
| HeLa | 11.2 | Medium expression |
| HepG2 | 9.5 | Medium expression |
| A549 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% (gnomAD) | Unknown functional effect |
| c.1246G>A (p.Val416Met) | Missense | <0.01% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • sodium:amino acid symporter activity (GO:0005283) | • neutral amino acid transmembrane transporter activity (GO:0015175) |
| • neutral amino acid transport (GO:0015804) | • integral component of plasma membrane (GO:0005887) |
| • integral component of membrane (GO:0016021) |
Pathways
• REACT:R-HSA-352230 – Amino acid transport across the plasma membrane
• REACT:R-HSA-425366 – Transport of inorganic cations/anions and amino acids/oligopeptides
• REACT:R-HSA-5619115 – Glutamine transport
Protein Summary
SLC38A7 encodes a 506-amino acid protein with 11 transmembrane domains. It functions as a sodium-coupled symporter for neutral amino acids, with highest affinity for glutamine. The protein localizes to the plasma membrane and is expressed in multiple tissues. It plays a key role in glutamine uptake, supporting cell growth and mTOR signaling. Overexpression in cancers suggests a role in metabolic reprogramming.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC38A7 Knockout HEK293 Cell Line | EDJ-KQ11457 | Human | 55238 | Details Get a Quote |
| SLC38A7 Knockout HeLa Cell Line | EDJ-KQ18192 | Human | 55238 | Details Get a Quote |
| SLC38A7 Knockout A-549 Cell Line | EDJ-KQ40987 | Human | 55238 | Details Get a Quote |
| SLC38A7 Knockout HCT 116 Cell Line | EDJ-KQ40989 | Human | 55238 | Details Get a Quote |
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