SLC38A10: Solute Carrier Family 38 Member 10
A sodium-coupled neutral amino acid transporter with roles in cellular nutrition and signaling.
Gene Information Card
| Symbol | SLC38A10 |
|---|---|
| Full Name | Solute carrier family 38 member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 124565 ncbi.nlm.nih.gov/gene/124565 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q9HBR0 |
| OMIM ID | 616525 |
| HGNC ID | 26979 |
| Aliases | SNAT10, PP1744, FLJ11236 |
Description
SLC38A10 encodes a member of the solute carrier family 38 (SLC38) of sodium-coupled neutral amino acid transporters. The protein mediates the transport of neutral amino acids across cellular membranes, playing a role in amino acid homeostasis, nutrient sensing, and mTOR signaling. It is widely expressed and may influence cell growth and metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect amino acid availability and mTOR pathway activity; somatic mutations observed in tumors. | COSMIC; literature |
| Neurodevelopmental disorders | Potential role due to expression in brain and involvement in amino acid transport. | ClinVar; limited evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 10.1 | Medium |
| Testis | 15.2 | High |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.0 | High expression |
| HeLa | 11.2 | Medium expression |
| HepG2 | 9.5 | Medium expression |
| K562 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% | Unknown; predicted benign |
| c.567delA | Frameshift | <0.001% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, impairing amino acid transport.
Gain of Function (GOF)
Not documented in curated databases.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • plasma membrane (GO:0005886) |
| • integral component of membrane (GO:0016021) | • amino acid transport (GO:0006865) |
| • sodium-dependent amino acid transport (GO:0035725) |
Pathways
• Amino acid transport across the plasma membrane
• mTOR signaling (indirect via amino acid sensing)
Protein Summary
The SLC38A10 protein (UniProt Q9HBR0) is a 541-amino acid multi-pass transmembrane protein localized to the plasma membrane. It functions as a sodium-coupled neutral amino acid transporter, importing small neutral amino acids such as alanine, serine, and glutamine. It is involved in cellular amino acid homeostasis and may modulate mTORC1 signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC38A10 Knockout HEK293 Cell Line | EDJ-KQ3910 | Human | 124565 | Details Get a Quote |
| SLC38A10 Knockout A-549 Cell Line | EDJ-KQ26132 | Human | 124565 | Details Get a Quote |
| SLC38A10 Knockout HeLa Cell Line | EDJ-KQ26133 | Human | 124565 | Details Get a Quote |
| SLC38A10 Knockout HCT 116 Cell Line | EDJ-KQ24789 | Human | 124565 | Details Get a Quote |
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