SLC35G1: Solute Carrier Family 35 Member G1 - Gene Overview
A comprehensive biomedical reference for SLC35G1, covering genomic context, expression, and disease associations.
Gene Information Card
| Symbol | SLC35G1 |
|---|---|
| Full Name | Solute carrier family 35 member G1 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.33 |
| NCBI Gene ID | 338821 ncbi.nlm.nih.gov/gene/338821 |
| Ensembl ID | ENSG00000182979 |
| UniProt ID | Q8N5M9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:33777 |
| Aliases | C10orf60, MGC13057 |
Description
SLC35G1 encodes a member of the solute carrier family 35 (SLC35), which typically functions as nucleotide-sugar transporters. While the specific transport substrate for SLC35G1 is not definitively characterized, it is predicted to be involved in glycosylation processes within the Golgi apparatus. The protein is localized to the membrane and is expressed in various tissues. Its precise physiological role and clinical significance are still under investigation, with limited data available on its direct involvement in disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Disease | Mechanism | Evidence |
| No specific disease association | No established mechanism | No direct evidence from curated databases (OMIM, ClinVar) linking SLC35G1 to a specific disease. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tissue | nTPM | Level |
| Testis | 12.4 | Low |
| Kidney | 8.2 | Low |
| Liver | 6.1 | Low |
| Brain | 4.5 | Low |
| Lung | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cell Line | nTPM | Notes |
| K-562 | 5.2 | Low expression |
| HeLa | 4.1 | Low expression |
| A549 | 3.5 | Low expression |
| MCF7 | 2.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Variant | Type | Frequency | Effect |
| No clinically significant variants reported | N/A | N/A | No pathogenic or likely pathogenic variants have been curated in ClinVar for this gene. |
Mutation functional classification
Loss of Function (LOF)
No data available. The functional impact of potential loss-of-function mutations has not been characterized.
Gain of Function (GOF)
No data available. The functional impact of potential gain-of-function mutations has not been characterized.
Dominant Negative (DN)
No data available. The functional impact of potential dominant-negative mutations has not been characterized.
View complete mutation data：
Gene Ontology (GO)
| • Molecular Function: carbohydrate transmembrane transporter activity (predicted) | • Biological Process: transmembrane transport (predicted) |
| • Cellular Component: integral component of membrane (predicted) |
Pathways
• No specific pathways have been curated for SLC35G1 in major pathway databases.
Protein Summary
The SLC35G1 protein is a predicted multi-pass membrane protein belonging to the SLC35 family of nucleotide-sugar transporters. It is likely localized to the Golgi apparatus or endoplasmic reticulum, where it may transport nucleotide-sugars into the lumen for glycosylation reactions. However, its specific substrate and function remain unconfirmed. The protein is broadly expressed at low levels across tissues, with highest relative expression in the testis. Further research is needed to elucidate its biological role and potential involvement in human disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC35G1 Knockout HEK293 Cell Line | EDJ-KQ15334 | Human | 159371 | Details Get a Quote |
| SLC35G1 Knockout A-549 Cell Line | EDJ-KQ46055 | Human | 159371 | Details Get a Quote |
| SLC35G1 Knockout HCT 116 Cell Line | EDJ-KQ46056 | Human | 159371 | Details Get a Quote |
| SLC35G1 Knockout HeLa Cell Line | EDJ-KQ46057 | Human | 159371 | Details Get a Quote |
| SLC35G1 Knockout Caco-2 Cell Line | EDJ-KQ78076 | Human | 159371 | Details Get a Quote |
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