SLC35F2: Solute Carrier Family 35 Member F2
A nucleotide-sugar transporter with emerging roles in cancer and glycosylation
Gene Information Card
| Symbol | SLC35F2 |
|---|---|
| Full Name | Solute Carrier Family 35 Member F2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q23.1 |
| NCBI Gene ID | 54733 ncbi.nlm.nih.gov/gene/54733 |
| Ensembl ID | ENSG00000110651 |
| UniProt ID | Q8IXU6 |
| OMIM ID | 618425 |
| HGNC ID | 20773 |
| Aliases | HSS1, MGC13170, dJ248O5.1 |
Description
SLC35F2 encodes a member of the solute carrier family 35 (SLC35) of nucleotide-sugar transporters. These proteins are localized to the Golgi apparatus and endoplasmic reticulum and mediate the transport of nucleotide sugars into the lumen, which is essential for proper glycosylation of proteins and lipids. SLC35F2 has been implicated in cancer cell proliferation and chemoresistance, and its expression is altered in several malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression of SLC35F2 is associated with increased cell proliferation and poor prognosis; may modulate glycosylation pathways affecting tumor progression. | PubMed: 25636840 |
| Gastric cancer | Upregulation of SLC35F2 correlates with lymph node metastasis and advanced TNM stage; potential biomarker. | PubMed: 27323851 |
| Hepatocellular carcinoma | SLC35F2 knockdown reduces cell viability and induces apoptosis; linked to altered N-glycosylation. | PubMed: 30323247 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 14.2 | Medium |
| Kidney | 11.8 | Medium |
| Colon | 9.5 | Low |
| Lung | 8.1 | Low |
| Breast | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver cancer) | 15.0 | High expression |
| HT-29 (colorectal cancer) | 12.4 | Moderate expression |
| A549 (lung cancer) | 7.8 | Low expression |
| MCF7 (breast cancer) | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104G>A (p.Arg35His) | Missense | <0.01% (gnomAD) | Unknown; predicted benign by SIFT |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% (gnomAD) | Unknown; predicted possibly damaging by PolyPhen-2 |
| c.832_833insA | Frameshift | <0.01% (COSMIC) | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions (e.g., c.832_833insA) are predicted to cause premature truncation and loss of transporter activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SLC35F2.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000139~Golgi membrane | • GO:0005459~UDP-galactose transmembrane transporter activity |
| • GO:0015780~UDP-galactose transport | • GO:0015781~UDP-N-acetylglucosamine transport |
| • GO:0015782~UDP-glucose transport |
Pathways
• Nucleotide-sugar transport (Reactome: R-HSA-425407)
• Glycosylation of proteins (Reactome: R-HSA-446203)
Protein Summary
SLC35F2 is a multi-pass transmembrane protein localized to the Golgi apparatus. It functions as a nucleotide-sugar transporter, likely mediating the import of UDP-galactose, UDP-N-acetylglucosamine, and UDP-glucose into the Golgi lumen. This activity is critical for the biosynthesis of glycoproteins and glycolipids. The protein consists of 10 predicted transmembrane domains and is expressed in various tissues, with highest levels in liver and kidney. Altered expression has been linked to cancer progression and chemoresistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC35F2 Knockout HEK293 Cell Line | EDJ-KQ12029 | Human | 54733 | Details Get a Quote |
| SLC35F2 Knockout HCT 116 Cell Line | EDC08637 | Human | 54733 | Details Get a Quote |
| SLC35F2 Knockout A-549 Cell Line | EDJ-KQ40637 | Human | 54733 | Details Get a Quote |
| SLC35F2 Knockout HeLa Cell Line | EDJ-KQ40639 | Human | 54733 | Details Get a Quote |
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