SLC2A13 Gene - Glucose/Fructose Transporter | Function, Expression & Disease

SLC2A13 (Solute Carrier Family 2 Member 13) encodes a proton-coupled myo-inositol and glucose transporter, also known as HMT (H(+)-myo-inositol symporter) or GLUT13. It belongs to the facilitative glucose transporter family but functions as a symporter driven by a proton gradient. The protein is highly expressed in brain, particularly in hippocampus and cerebellum, and is involved in myo-inositol homeostasis, which is critical for osmoregulation and cell signaling. SLC2A13 has been implicated in metabolic disorders and neurological conditions.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• REACT: R-HSA-425407 (SLC-mediated transmembrane transport)

• REACT: R-HSA-425393 (Transport of glucose and other sugars

• bile salts and organic acids

• metal ions and amine compounds)

• REACT: R-HSA-189200 (Cellular hexose transport)

The SLC2A13 protein (HMT/GLUT13) is a 648-amino acid transmembrane transporter with 12 predicted helical domains. It functions as a proton-coupled symporter for myo-inositol and, to a lesser extent, glucose and fructose. The protein is predominantly expressed in brain, where it regulates myo-inositol levels, influencing osmoregulation, phosphoinositide signaling, and neuronal function. Structural studies indicate a conserved sugar-binding pocket and proton-binding site essential for transport activity.