SLC26A1 Gene - Oxalate Transporter | Function, Mutations & Diseases

SLC26A1 (Solute Carrier Family 26 Member 1) encodes a transmembrane protein that functions as an oxalate and sulfate transporter. It is primarily expressed in the kidney and liver, where it mediates the exchange of oxalate and sulfate across the plasma membrane. This gene plays a critical role in oxalate homeostasis and has been implicated in the pathogenesis of calcium oxalate kidney stones. Mutations in SLC26A1 can lead to altered oxalate transport and increased risk of nephrolithiasis.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Oxalate transport and metabolism

• Sulfate transport

• SLC-mediated transmembrane transport

The SLC26A1 protein (SAT1) is a 722-amino acid multi-pass transmembrane protein belonging to the SLC26 family of anion exchangers. It mediates the electroneutral exchange of oxalate and sulfate across the plasma membrane, with a preference for oxalate. The protein is highly expressed in the basolateral membrane of renal proximal tubule cells and hepatocytes, where it facilitates the excretion of oxalate into the urine and bile. Structural studies indicate a conserved sulfate transporter domain. Dysfunction of SLC26A1 leads to accumulation of oxalate, contributing to calcium oxalate crystal formation and kidney stone disease.