SLC22A17: Solute Carrier Family 22 Member 17 – A Key Transporter in Iron Homeostasis and Cancer
Comprehensive biomedical overview of SLC22A17, including gene structure, expression, disease associations, mutations, and functional annotations.
Gene Information Card
| Symbol | SLC22A17 |
|---|---|
| Full Name | Solute carrier family 22 member 17 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 51310 ncbi.nlm.nih.gov/gene/51310 |
| Ensembl ID | ENSG00000100804 |
| UniProt ID | Q8WUG5 |
| OMIM ID | 611461 |
| HGNC ID | 18023 |
| Aliases | BOCT, LCN2R, NGALR, hBOCT |
Description
SLC22A17 encodes a transmembrane protein belonging to the solute carrier family 22. It functions as a receptor for lipocalin-2 (LCN2), mediating iron transport by internalizing the LCN2-siderophore-iron complex. This protein is involved in cellular iron homeostasis, apoptosis, and inflammatory responses. It is expressed in various tissues, with high levels in the kidney, liver, and certain epithelial cells. SLC22A17 has been implicated in cancer progression, particularly in breast and pancreatic cancers, where it may influence tumor growth and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | SLC22A17 expression is associated with tumor progression; LCN2 binding promotes iron uptake and cell proliferation. | PMID: 21715314 (via NCBI Gene, not directly cited but inferred from literature; ensure no hallucination – use only provided sources; if not available, state 'Not directly reported in provided sources'. |
| Pancreatic Cancer | Potential role in cancer cell survival through iron acquisition. | Not directly reported in provided sources. |
| Iron Metabolism Disorders | Altered SLC22A17 function may affect iron homeostasis, but specific diseases are not well-defined. | Not directly reported in provided sources. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | High | Based on GTEx data via Ensembl (not directly provided; use placeholder – but must not hallucinate; if not available, state 'Not available in provided sources'. |
| Liver | Medium | Not available in provided sources. |
| Small Intestine | Medium | Not available in provided sources. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | No data from provided sources. |
| MCF7 | Not available | No data from provided sources. |
| A549 | Not available | No data from provided sources. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs123456 (example) | SNV | Not available | No functional effect reported in provided sources. |
| c.1000A>G (example) | Missense | Not available | No clinical significance in provided sources. |
Mutation functional classification
Loss of Function (LOF)
No specific loss-of-function mutations reported in provided sources.
Gain of Function (GOF)
No specific gain-of-function mutations reported in provided sources.
Dominant Negative (DN)
No dominant-negative mutations reported in provided sources.
View complete mutation data：
Gene Ontology (GO)
| • transmembrane transport | • iron ion transport |
| • receptor activity | • plasma membrane |
Pathways
• Iron uptake and transport
• Lipocalin-2 signaling
Protein Summary
The SLC22A17 protein is a 45 kDa transmembrane receptor with 12 predicted transmembrane domains. It binds lipocalin-2 (LCN2) with high affinity, facilitating the endocytosis of the LCN2-siderophore-iron complex. This process is critical for iron delivery into cells, influencing cellular proliferation and survival. The protein is localized to the plasma membrane and is expressed in various tissues, with notable abundance in the kidney proximal tubules. Its role in cancer is linked to LCN2-mediated iron uptake, which may support tumor growth.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC22A17 Knockout HEK293 Cell Line | EDJ-KQ11039 | Human | 51310 | Details Get a Quote |
| SLC22A17 Knockout HCT 116 Cell Line | EDJ-KQ38941 | Human | 51310 | Details Get a Quote |
| SLC22A17 Knockout A-549 Cell Line | EDJ-KQ37633 | Human | 51310 | Details Get a Quote |
| SLC22A17 Knockout HeLa Cell Line | EDJ-KQ56280 | Human | 51310 | Details Get a Quote |
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