SLC16A6: Solute Carrier Family 16 Member 6
Monocarboxylate Transporter 6 (MCT6) - Gene Overview
Gene Information Card
| Symbol | SLC16A6 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q24.2 |
| NCBI Gene ID | 9120 ncbi.nlm.nih.gov/gene/9120 |
| Ensembl ID | ENSG00000108932 |
| UniProt ID | Q9Y6M7 |
| OMIM ID | 611225 |
| HGNC ID | 10926 |
| Aliases | MCT6, MCT 6 |
Description
SLC16A6 (Solute Carrier Family 16 Member 6) encodes monocarboxylate transporter 6 (MCT6), a proton-coupled transporter of monocarboxylates such as lactate, pyruvate, and ketone bodies. MCT6 is involved in cellular metabolism and pH regulation. The gene is located on chromosome 17q24.2 and is expressed in multiple tissues, including kidney, liver, and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lactic acidosis | Impaired lactate transport due to SLC16A6 dysfunction | PMID: 23451113 |
| Metabolic syndrome | Altered monocarboxylate transport affecting energy homeostasis | PMID: 25687211 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Brain | 6.1 | Low |
| Heart | 4.2 | Low |
| Skeletal Muscle | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HepG2 | 9.7 | Moderate expression |
| SH-SY5Y | 5.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
| c.452G>A (p.Arg151Gln) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not reported in ClinVar or COSMIC for SLC16A6.
Gain of Function (GOF)
Not reported in ClinVar or COSMIC for SLC16A6.
Dominant Negative (DN)
Not reported in ClinVar or COSMIC for SLC16A6.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Monocarboxylate transport (Reactome: R-HSA-433692)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
MCT6 (UniProt Q9Y6M7) is a 12-transmembrane domain protein that mediates proton-coupled transport of monocarboxylates. It is localized to the plasma membrane and plays a role in cellular lactate and ketone body shuttling. The protein is expressed in kidney, liver, and brain, and may be involved in metabolic regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A6 Knockout HEK293 Cell Line | EDJ-KQ6465 | Human | 9120 | Details Get a Quote |
| SLC16A6 Knockout HCT 116 Cell Line | EDJ-KQ30550 | Human | 9120 | Details Get a Quote |
| SLC16A6 Knockout HeLa Cell Line | EDJ-KQ30551 | Human | 9120 | Details Get a Quote |
| SLC16A6 Knockout A-549 Cell Line | EDJ-KQ63568 | Human | 9120 | Details Get a Quote |
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