SLC16A13
Solute Carrier Family 16 Member 13
Gene Information Card
| Symbol | SLC16A13 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 201232 ncbi.nlm.nih.gov/gene/201232 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q7Z7H8 |
| OMIM ID | 616161 |
| HGNC ID | 26462 |
| Aliases | MCT13, MCT-13 |
Description
SLC16A13 (Solute Carrier Family 16 Member 13) is a protein-coding gene that encodes a member of the monocarboxylate transporter (MCT) family. The protein is predicted to transport monocarboxylates such as lactate, pyruvate, and ketone bodies across the plasma membrane. It is expressed in various tissues and has been implicated in metabolic processes and certain diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 diabetes | Genetic association studies have linked SLC16A13 variants to altered risk of type 2 diabetes, possibly through effects on lactate transport and insulin secretion. | GWAS and meta-analysis (PMID: 24509480) |
| Hyperuricemia | SLC16A13 polymorphisms have been associated with serum uric acid levels and gout risk. | Genome-wide association study (PMID: 23263486) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.3 | Low |
| Kidney | 1.8 | Low |
| Heart | 0.9 | Not detected |
| Brain | 0.5 | Not detected |
| Skeletal Muscle | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 1.5 | Hepatocellular carcinoma cell line |
| HEK293 | 0.8 | Embryonic kidney cells |
| K562 | 0.2 | Chronic myelogenous leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1171614 | SNP | 0.15 (East Asian) | Intronic variant associated with type 2 diabetes risk |
| rs1171615 | SNP | 0.10 (European) | Associated with uric acid levels |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • symporter activity (GO:0015293) |
| • monocarboxylate transport (GO:0015718) | • plasma membrane (GO:0005886) |
Pathways
• Monocarboxylate transport (Reactome: R-HSA-433137)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
The SLC16A13 protein (UniProt Q7Z7H8) is a predicted 12-transmembrane domain transporter belonging to the monocarboxylate transporter family. It is thought to facilitate the proton-coupled transport of monocarboxylates such as lactate and pyruvate. Its exact substrate specificity and physiological role remain under investigation, but genetic studies link it to metabolic traits.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A13 Knockout HEK293 Cell Line | EDJ-KQ3990 | Human | 201232 | Details Get a Quote |
| SLC16A13 Knockout A-549 Cell Line | EDJ-KQ27528 | Human | 201232 | Details Get a Quote |
| SLC16A13 Knockout HCT 116 Cell Line | EDJ-KQ27530 | Human | 201232 | Details Get a Quote |
| SLC16A13 Knockout HeLa Cell Line | EDJ-KQ27531 | Human | 201232 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
