SLC16A11
Solute Carrier Family 16 Member 11
Gene Information Card
| Symbol | SLC16A11 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 162515 ncbi.nlm.nih.gov/gene/162515 |
| Ensembl ID | ENSG00000166863 |
| UniProt ID | Q8NCK7 |
| OMIM ID | 615242 |
| HGNC ID | 22982 |
| Aliases | MCT11, MCT 11 |
Description
SLC16A11 (Solute Carrier Family 16 Member 11) encodes a member of the monocarboxylate transporter (MCT) family. The protein is involved in the transport of monocarboxylates such as lactate and pyruvate across the plasma membrane. Genetic variants in SLC16A11 have been associated with increased risk of type 2 diabetes, particularly in East Asian and Mexican populations. The gene is expressed in multiple tissues including liver, kidney, and adipose tissue.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes Mellitus | Risk variant (rs13342232, rs75493593) alters transporter function or expression, affecting lactate/pyruvate metabolism and insulin sensitivity | GWAS studies in East Asian and Mexican populations (PMID: 24509480, 25485910) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.3 | Low |
| Kidney | 1.8 | Low |
| Adipose Tissue | 1.5 | Low |
| Thyroid | 1.2 | Low |
| Skin | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 0.5 | Low expression |
| HEK293 | 0.3 | Low expression |
| MCF7 | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs13342232 (G>A) | SNV | 0.10 (East Asian) | Risk allele for type 2 diabetes; associated with reduced SLC16A11 expression |
| rs75493593 (T>C) | SNV | 0.08 (Mexican) | Risk allele; alters splicing or regulatory element |
| rs117767867 (C>G) | SNV | 0.02 (East Asian) | Missense variant (p.Pro156Ala); functional impact uncertain |
Mutation functional classification
Loss of Function (LOF)
rs13342232 risk allele is associated with reduced SLC16A11 mRNA expression in liver and adipose, suggesting loss of function.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative mechanism described.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • monocarboxylate transport (GO:0015718) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
Pathways
• Monocarboxylate transport (Reactome: R-HSA-433137)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
SLC16A11 is a 12-transmembrane domain protein belonging to the monocarboxylate transporter family. It facilitates the proton-coupled transport of monocarboxylates such as lactate and pyruvate. The protein is localized to the plasma membrane and is expressed in metabolic tissues. Structural modeling suggests a conserved substrate-binding pocket. Variants associated with type 2 diabetes may impair transporter activity or membrane localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A11 Knockout HEK293 Cell Line | EDJ-KQ15298 | Human | 162515 | Details Get a Quote |
| SLC16A11 Knockout HeLa Cell Line | EDJ-KQ58840 | Human | 162515 | Details Get a Quote |
| SLC16A11 Knockout A-549 Cell Line | EDJ-KQ67328 | Human | 162515 | Details Get a Quote |
| SLC16A11 Knockout HCT 116 Cell Line | EDJ-KQ75723 | Human | 162515 | Details Get a Quote |
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