SLC16A10: Solute Carrier Family 16 Member 10
Monocarboxylate Transporter 10 (MCT10) – Aromatic Amino Acid Transporter
Gene Information Card
| Symbol | SLC16A10 |
|---|---|
| Full Name | Solute Carrier Family 16 Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 117247 ncbi.nlm.nih.gov/gene/117247 |
| Ensembl ID | ENSG00000112394 |
| UniProt ID | Q8TF71 |
| OMIM ID | 607564 |
| HGNC ID | 10981 |
| Aliases | MCT10, TAT1, PRO0818 |
Description
SLC16A10 (Solute Carrier Family 16 Member 10) encodes the monocarboxylate transporter 10 (MCT10), also known as T-type amino acid transporter 1 (TAT1). This protein mediates the sodium-independent transport of aromatic amino acids (e.g., phenylalanine, tyrosine, tryptophan) and thyroid hormones (T3, T4) across plasma membranes. It is widely expressed in tissues such as kidney, intestine, liver, and placenta, playing a key role in amino acid homeostasis and thyroid hormone metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Thyroid hormone resistance (impaired transport) | Defective T3/T4 uptake due to SLC16A10 variants | PMID: 18434324 |
| Phenylketonuria (modifier) | Altered phenylalanine transport may influence metabolic phenotype | PMID: 21326311 |
| Hypertension (association) | Polymorphisms in SLC16A10 linked to blood pressure regulation | PMID: 21738479 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 45.2 | High |
| Small intestine | 38.7 | High |
| Liver | 22.1 | Medium |
| Placenta | 18.5 | Medium |
| Skeletal muscle | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.4 | Moderate expression |
| Caco-2 | 28.9 | High expression (intestinal model) |
| HepG2 | 15.6 | Moderate expression |
| RPTEC | 40.1 | High expression (kidney proximal tubule) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.119C>T (p.Pro40Leu) | Missense | 0.02% (gnomAD) | Reduced transport activity in vitro |
| c.467G>A (p.Arg156His) | Missense | 0.01% (gnomAD) | Altered substrate specificity |
| c.832G>A (p.Gly278Ser) | Missense | 0.005% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Pro40Leu reduces T3 uptake in cellular assays.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not described for SLC16A10.
View complete mutation data：
Gene Ontology (GO)
| • amino acid transmembrane transporter activity (GO:0015171) | • L-amino acid transmembrane transporter activity (GO:0015179) |
| • symporter activity (GO:0015293) | • integral component of plasma membrane (GO:0005887) |
| • amino acid transport (GO:0006865) | • thyroid hormone transmembrane transport (GO:0070324) |
Pathways
• REACT:17015 – Transport of amino acids
• REACT:17016 – Transport of organic anions
• REACT:17017 – Thyroid hormone transport
Protein Summary
MCT10 (UniProt Q8TF71) is a 515-amino acid transmembrane protein with 12 predicted alpha-helical domains. It functions as a sodium-independent, bidirectional transporter for aromatic amino acids and thyroid hormones. The protein is localized to the basolateral membrane of epithelial cells in kidney and intestine, facilitating efflux of amino acids into the bloodstream. Its structure includes a large intracellular loop between transmembrane domains 6 and 7, critical for substrate recognition.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC16A10 Knockout HEK293 Cell Line | EDJ-KQ7604 | Human | 117247 | Details Get a Quote |
| SLC16A10 Knockout A-549 Cell Line | EDJ-KQ32943 | Human | 117247 | Details Get a Quote |
| SLC16A10 Knockout HCT 116 Cell Line | EDJ-KQ31597 | Human | 117247 | Details Get a Quote |
| SLC16A10 Knockout HeLa Cell Line | EDJ-KQ58012 | Human | 117247 | Details Get a Quote |
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