SLC15A2: Solute Carrier Family 15 Member 2
Proton-coupled peptide transporter PEPT2
Gene Information Card
| Symbol | SLC15A2 |
|---|---|
| Full Name | Solute Carrier Family 15 Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q13.33 |
| NCBI Gene ID | 6565 ncbi.nlm.nih.gov/gene/6565 |
| Ensembl ID | ENSG00000114686 |
| UniProt ID | Q16348 |
| OMIM ID | 602339 |
| HGNC ID | 10921 |
| Aliases | PEPT2, PTR2, hPEPT2 |
Description
SLC15A2 encodes a proton-coupled oligopeptide transporter (PEPT2) that mediates the electrogenic uptake of di- and tripeptides, as well as peptide-like drugs, across the apical membrane of epithelial cells. It is highly expressed in kidney, lung, and choroid plexus, playing a key role in peptide reabsorption and drug disposition.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic kidney disease | Altered peptide transport may affect drug clearance and toxin accumulation | PMID: 25687213 |
| Cystinuria | Potential modifier of amino acid transport; indirect evidence | OMIM #220100 |
| Drug-induced nephrotoxicity | SLC15A2 transports nephrotoxic peptide-mimetic drugs (e.g., cephalosporins) | PMID: 16951179 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 68.2 | High |
| Lung | 32.5 | Medium |
| Choroid plexus | 45.1 | Medium |
| Small intestine | 12.3 | Low |
| Liver | 5.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HK-2 (kidney proximal tubule) | 89.4 | High expression |
| Caco-2 (intestinal) | 22.1 | Moderate expression |
| A549 (lung) | 41.7 | High expression |
| HepG2 (liver) | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1508G>A (p.Arg503Gln) | Missense | 0.0002 (gnomAD) | Reduced transport activity in vitro |
| c.1120C>T (p.Arg374Trp) | Missense | 0.0001 (gnomAD) | Altered substrate specificity |
| c.1966C>T (p.Arg656Cys) | Missense | 0.0003 (gnomAD) | Decreased protein stability |
Mutation functional classification
Loss of Function (LOF)
p.Arg503Gln and p.Arg656Cys reduce peptide uptake in cell-based assays.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • transporter activity (GO:0005215) | • symporter activity (GO:0015293) |
| • oligopeptide transmembrane transporter activity (GO:0015321) | • peptide transport (GO:0015886) |
| • integral component of plasma membrane (GO:0005887) | • transmembrane transport (GO:0055085) |
Pathways
• Proton-coupled oligopeptide transport (Reactome: R-HSA-382556)
• Drug absorption and disposition (KEGG: hsa04976)
Protein Summary
PEPT2 is a 729-amino acid transmembrane protein with 12 predicted helices. It functions as a proton-coupled symporter, utilizing an inward proton gradient to drive the uptake of small peptides and peptidomimetic drugs. It is critical for renal reabsorption of filtered peptides and for drug delivery across the blood-cerebrospinal fluid barrier.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC15A2 Knockout HEK293 Cell Line | EDJ-KQ5786 | Human | 6565 | Details Get a Quote |
| SLC15A2 Knockout HCT 116 Cell Line | EDJ-KQ29206 | Human | 6565 | Details Get a Quote |
| SLC15A2 Knockout HeLa Cell Line | EDJ-KQ54510 | Human | 6565 | Details Get a Quote |
| SLC15A2 Knockout A-549 Cell Line | EDJ-KQ62996 | Human | 6565 | Details Get a Quote |
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