SLC10A1 (NTCP): Sodium-Taurocholate Cotransporting Polypeptide
Key bile acid transporter and hepatitis B/D virus receptor
Gene Information Card
| Symbol | SLC10A1 |
|---|---|
| Full Name | Solute Carrier Family 10 Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q24.1 |
| NCBI Gene ID | 6554 ncbi.nlm.nih.gov/gene/6554 |
| Ensembl ID | ENSG00000170652 |
| UniProt ID | Q14973 |
| OMIM ID | 182396 |
| HGNC ID | 10905 |
| Aliases | NTCP, NTCP1, GIG29 |
Description
SLC10A1 encodes the sodium-taurocholate cotransporting polypeptide (NTCP), a transmembrane protein primarily expressed in the liver. NTCP mediates the uptake of bile acids from portal blood into hepatocytes, playing a critical role in enterohepatic circulation. It also serves as the cellular receptor for hepatitis B and D viruses, facilitating viral entry into hepatocytes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypercholanemia, familial | Loss-of-function mutations in SLC10A1 impair bile acid transport, leading to elevated serum bile acid levels. | OMIM 182396; PMID 25557789 |
| Hepatitis B virus infection | NTCP acts as the receptor for HBV; polymorphisms may affect susceptibility or response to infection. | PMID 23149947; PMID 25557789 |
| Hepatitis D virus infection | HDV requires NTCP for entry; NTCP expression is essential for co-infection with HBV. | PMID 23149947 |
| Cholestasis | Reduced NTCP function can contribute to cholestatic liver disease, though SLC10A1 mutations are rare. | PMID 25557789 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | High (nTPM ~ 200) | Predominant expression in hepatocytes |
| Kidney | Low (nTPM ~ 5) | Minimal expression in renal tubules |
| Small intestine | Low (nTPM ~ 3) | Low expression in enterocytes |
| Other tissues | Not detected | No significant expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | High | Hepatocellular carcinoma cell line |
| Huh7 | High | Hepatoma cell line |
| HEK293 | Low | When overexpressed, used for functional studies |
| Caco-2 | Low | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Ser267Phe | Missense | Rare (allele frequency <0.1%) | Loss of bile acid transport; reduces HBV entry |
| p.Arg252His | Missense | Rare | Impaired transport activity |
| p.Ile223Thr | Missense | Rare | Reduced cell surface expression |
| p.Leu294Trp | Missense | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Most SLC10A1 mutations result in loss of bile acid transport function, leading to hypercholanemia.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative effects described; disease is typically autosomal recessive.
View complete mutation data：
Gene Ontology (GO)
| • bile acid:sodium symporter activity (GO:0008508) | • symporter activity (GO:0015293) |
| • integral component of membrane (GO:0016021) | • integral component of plasma membrane (GO:0005887) |
| • bile acid metabolic process (GO:0008203) | • bile acid transport (GO:0015721) |
Pathways
• Bile acid transport and enterohepatic circulation
• Hepatitis B virus entry into hepatocytes
Protein Summary
NTCP is a 349-amino acid protein with seven transmembrane domains. It functions as a symporter, coupling sodium ion influx to bile acid uptake. The protein is heavily glycosylated and localized to the basolateral membrane of hepatocytes. Its structure includes a large extracellular loop that is critical for HBV receptor function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC10A1 Knockout HEK293 Cell Line | EDJ-KQ2393 | Human | 6554 | Details Get a Quote |
| SLC10A1 Knockout HeLa Cell Line | EDJ-KQ54503 | Human | 6554 | Details Get a Quote |
| SLC10A1 Knockout A-549 Cell Line | EDJ-KQ62988 | Human | 6554 | Details Get a Quote |
| SLC10A1 Knockout HCT 116 Cell Line | EDJ-KQ71459 | Human | 6554 | Details Get a Quote |
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