SIRT2: Sirtuin 2 - A Key Regulator of Aging, Metabolism, and Cancer
Comprehensive gene card for SIRT2, including genomic data, expression, mutations, and disease associations.
Gene Information Card
| Symbol | SIRT2 |
|---|---|
| Full Name | Sirtuin 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 22933 ncbi.nlm.nih.gov/gene/22933 |
| Ensembl ID | ENSG00000068903 |
| UniProt ID | Q8IXJ6 |
| OMIM ID | 604480 |
| HGNC ID | 10886 |
| Aliases | SIR2L, SIR2L2, SIR2-like 2 |
Description
SIRT2 is a member of the sirtuin family of NAD-dependent deacetylases, involved in cellular processes such as cell cycle regulation, genome stability, metabolism, and aging. It deacetylates histones and non-histone proteins, including alpha-tubulin and p53, and has been implicated in cancer, neurodegenerative diseases, and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (breast, liver, glioma) | SIRT2 deacetylates and stabilizes oncoproteins or tumor suppressors; altered expression promotes proliferation or metastasis. | COSMIC, NCBI, ClinVar |
| Parkinson's disease | SIRT2 deacetylates alpha-synuclein and modulates its aggregation; inhibition reduces neurotoxicity. | NCBI, OMIM |
| Metabolic syndrome | SIRT2 regulates insulin signaling and lipid metabolism via deacetylation of FOXO1 and other targets. | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 8.3 | Low |
| Breast | 6.7 | Low |
| Testis | 15.2 | Medium |
| Heart | 4.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| HepG2 | 9.4 | Liver cancer cell line |
| SH-SY5Y | 11.2 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.354G>A (p.Met118Ile) | Missense | <0.1% | Alters deacetylase activity; reported in COSMIC |
| c.497C>T (p.Thr166Met) | Missense | <0.1% | Found in cancer samples; functional impact unknown |
| c.1-?_*_del | Deletion | Rare | Loss of function; associated with altered cell cycle |
Mutation functional classification
Loss of Function (LOF)
Deletions or missense mutations reducing deacetylase activity may impair cell cycle control and promote genomic instability.
Gain of Function (GOF)
Rare; some missense variants may enhance deacetylase activity, potentially affecting oncogenic pathways.
Dominant Negative (DN)
Not well documented; possible in cases where mutant SIRT2 interferes with wild-type function.
View complete mutation data：
Gene Ontology (GO)
| • NAD-dependent histone deacetylase activity (H3K16 specific) | • Protein deacetylase activity |
| • Chromatin binding | • Cell cycle |
| • DNA repair | • Microtubule cytoskeleton organization |
Pathways
• p53 signaling pathway
• FOXO signaling pathway
• Circadian rhythm
• Longevity regulating pathway
Protein Summary
SIRT2 is a 389-amino acid NAD-dependent deacetylase predominantly cytoplasmic but shuttles to the nucleus. It deacetylates histones (H3K16, H4K16) and non-histone substrates (alpha-tubulin, p53, FOXO1, NF-kB). It regulates cell cycle progression, genomic stability, and metabolic homeostasis. Dysregulation is linked to cancer, neurodegeneration, and aging.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SIRT2 Knockout MH-S Cell Line | EDJ-KQ78173 | Mouse | 64383 | Details Get a Quote |
| SIRT2 Knockout HEK293 Cell Line | EDJ-KQ1129 | Human | 22933 | Details Get a Quote |
| SIRT2 Knockout A-549 Cell Line | EDJ-KQ18084 | Human | 22933 | Details Get a Quote |
| SIRT2 Knockout HCT 116 Cell Line | EDJ-KQ20331 | Human | 22933 | Details Get a Quote |
| SIRT2 Knockout HeLa Cell Line | EDJ-KQ20332 | Human | 22933 | Details Get a Quote |
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