SGTA: Small Glutamine Rich Tetratricopeptide Repeat Co-Chaperone Alpha
A comprehensive biomedical overview of SGTA gene, including genomic context, expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | SGTA |
|---|---|
| Full Name | Small glutamine rich tetratricopeptide repeat co-chaperone alpha |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 6449 ncbi.nlm.nih.gov/gene/6449 |
| Ensembl ID | ENSG00000104973 |
| UniProt ID | O43765 |
| OMIM ID | 601117 |
| HGNC ID | 10819 |
| Aliases | SGT, SGT1, hSGT, Vpu-binding protein |
Description
SGTA encodes a co-chaperone protein that contains tetratricopeptide repeats (TPR) and a glutamine-rich region. It interacts with Hsp70 and Hsp90, participating in protein quality control, steroid hormone receptor assembly, and viral protein trafficking. The gene is located on chromosome 19p13.3 and is ubiquitously expressed.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | SGTA overexpression may modulate androgen receptor signaling via Hsp90 interaction | PMID: 19160496 |
| Hepatocellular carcinoma | SGTA upregulation associated with poor prognosis; promotes cell proliferation | PMID: 25605247 |
| HIV-1 infection | SGTA binds HIV-1 Vpu protein, influencing viral release | PMID: 12504017 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 18.2 | Medium |
| Brain | 12.5 | Medium |
| Liver | 10.8 | Medium |
| Heart | 9.3 | Low |
| Lung | 8.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 22.1 | High expression |
| HeLa | 19.4 | High expression |
| HepG2 | 15.6 | Medium expression |
| K562 | 11.3 | Medium expression |
| A549 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.344C>T (p.Pro115Leu) | Missense | <0.01% | Unknown functional effect |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% | Unknown functional effect |
| c.1A>G (p.Met1?) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1?) are predicted to abolish protein translation.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • unfolded protein binding (GO:0051082) | • ubiquitin protein ligase binding (GO:0031625) |
| • chaperone binding (GO:0051087) | • protein folding (GO:0006457) |
| • cell differentiation (GO:0030154) |
Pathways
• Hsp90 chaperone cycle for steroid hormone receptors (Reactome: R-HSA-3371497)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
SGTA is a 313-amino acid co-chaperone with three TPR domains and a glutamine-rich region. It facilitates Hsp70/Hsp90-mediated protein folding, particularly for steroid receptors. It also participates in retrotranslocation of misfolded proteins from the endoplasmic reticulum and modulates viral protein trafficking. The protein is predominantly cytoplasmic but can shuttle to the nucleus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SGTA Knockout HEK293 Cell Line | EDJ-KQ2417 | Human | 6449 | Details Get a Quote |
| SGTA Knockout A-549 Cell Line | EDJ-KQ22924 | Human | 6449 | Details Get a Quote |
| SGTA Knockout HeLa Cell Line | EDJ-KQ22925 | Human | 6449 | Details Get a Quote |
| SGTA Knockout HCT 116 Cell Line | EDJ-KQ21600 | Human | 6449 | Details Get a Quote |
