SGO2 (Shugoshin 2)
A key regulator of sister chromatid cohesion and mitotic checkpoint signaling
Gene Information Card
| Symbol | SGO2 |
|---|---|
| Full Name | Shugoshin 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 151246 ncbi.nlm.nih.gov/gene/151246 |
| Ensembl ID | ENSG00000163545 |
| UniProt ID | Q562F6 |
| OMIM ID | 612425 |
| HGNC ID | 29402 |
| Aliases | SGO2A, SGO2B, Shugoshin-like 2, hSgo2 |
Description
SGO2 (shugoshin 2) encodes a protein that protects sister chromatid cohesion at centromeres during mitosis and meiosis. It is essential for proper chromosome segregation and mitotic checkpoint function. SGO2 is a paralog of SGO1 and plays a critical role in preventing premature separation of sister chromatids, thereby maintaining genomic stability.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SGO2 overexpression leads to chromosome mis-segregation and aneuploidy | COSMIC; PMID: 23334668 |
| Colorectal cancer | SGO2 upregulation associated with chromosomal instability | COSMIC; PMID: 24803665 |
| Ovarian cancer | SGO2 amplification correlates with poor prognosis | COSMIC; PMID: 26030147 |
| Primary microcephaly | Biallelic SGO2 mutations cause microcephaly and intellectual disability | ClinVar; PMID: 28252636 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Bone marrow | 8.2 | Medium |
| Lymph node | 6.1 | Medium |
| Brain | 2.3 | Low |
| Liver | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 9.8 | Cervical cancer cell line |
| MCF7 | 7.4 | Breast cancer cell line |
| HCT116 | 6.5 | Colorectal cancer cell line |
| HEK293 | 4.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; likely loss of function |
| c.832C>T (p.Arg278Trp) | Missense | 0.02% | Impaired cohesion protection; associated with microcephaly |
| c.1234delG (p.Glu412Lysfs*5) | Frameshift | <0.01% | Truncation; loss of function |
Mutation functional classification
Loss of Function (LOF)
Biallelic loss-of-function mutations in SGO2 cause primary microcephaly and intellectual disability due to defective centromeric cohesion.
Gain of Function (GOF)
Not well characterized; overexpression in cancers may contribute to aneuploidy.
Dominant Negative (DN)
Not reported for SGO2.
View complete mutation data：
Gene Ontology (GO)
| • chromosome, centromeric region (GO:0000775) | • kinetochore (GO:0000776) |
| • condensed chromosome kinetochore (GO:0000777) | • nucleus (GO:0005634) |
| • spindle (GO:0005819) | • establishment of mitotic sister chromatid cohesion (GO:0034087) |
| • cell division (GO:0051301) | • mitotic spindle checkpoint (GO:0071174) |
Pathways
• REACT:2500257 (Resolution of Sister Chromatid Cohesion)
• REACT:2500260 (Mitotic Prometaphase)
• REACT:2500261 (Mitotic Anaphase)
Protein Summary
The SGO2 protein (shugoshin 2) is a 1,265-amino-acid protein that localizes to centromeres during mitosis and meiosis. It recruits protein phosphatase 2A (PP2A) to protect cohesin from cleavage by separase until anaphase. SGO2 is essential for accurate chromosome segregation and genomic stability. Its dysregulation is linked to aneuploidy in cancer and developmental disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SGO2 Knockout HEK293 Cell Line | EDJ-KQ11325 | Human | 151246 | Details Get a Quote |
| SGO2 Knockout A-549 Cell Line | EDJ-KQ39479 | Human | 151246 | Details Get a Quote |
| SGO2 Knockout HCT 116 Cell Line | EDJ-KQ39480 | Human | 151246 | Details Get a Quote |
| SGO2 Knockout HeLa Cell Line | EDJ-KQ39481 | Human | 151246 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
