SFRP2 (Secreted Frizzled Related Protein 2)
A Wnt signaling modulator involved in development, fibrosis, and cancer
Gene Information Card
| Symbol | SFRP2 |
|---|---|
| Full Name | Secreted Frizzled Related Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q31.3 |
| NCBI Gene ID | 6423 ncbi.nlm.nih.gov/gene/6423 |
| Ensembl ID | ENSG00000145423 |
| UniProt ID | Q96HF1 |
| OMIM ID | 604156 |
| HGNC ID | 10777 |
| Aliases | FRP-2, SARP2, SDF-5 |
Description
SFRP2 encodes a member of the secreted frizzled-related protein (SFRP) family, which functions as a modulator of Wnt signaling. The protein contains a cysteine-rich domain homologous to the Wnt-binding site of frizzled receptors, allowing it to bind Wnt ligands and inhibit canonical and non-canonical Wnt pathways. SFRP2 plays roles in embryonic development, tissue homeostasis, and is implicated in fibrosis and tumorigenesis through epigenetic silencing or aberrant expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Promoter hypermethylation silences SFRP2, leading to constitutive Wnt activation and tumor progression | ClinVar, COSMIC |
| Breast cancer | Reduced SFRP2 expression correlates with poor prognosis; re-expression inhibits Wnt signaling and cell proliferation | NCBI Gene, OMIM |
| Pulmonary fibrosis | SFRP2 promotes fibroblast activation and extracellular matrix deposition via non-canonical Wnt signaling | NCBI Gene, PubMed |
| Osteoarthritis | SFRP2 dysregulation alters Wnt/β-catenin signaling in chondrocytes, contributing to cartilage degradation | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Lung | 8.7 | Low |
| Liver | 5.1 | Low |
| Kidney | 15.6 | Medium |
| Breast | 20.4 | Medium |
| Colon | 25.8 | High |
| Prostate | 18.2 | Medium |
| Ovary | 22.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 45.2 | High expression |
| HCT116 (colorectal cancer) | 38.7 | High expression |
| A549 (lung cancer) | 12.1 | Low expression |
| HEK293 (embryonic kidney) | 30.5 | Medium expression |
| HepG2 (liver cancer) | 8.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Loss of start codon; likely loss of function |
| c.202C>T (p.Arg68Trp) | Missense | <0.1% | Unknown significance; reported in COSMIC |
| c.454G>A (p.Gly152Ser) | Missense | <0.1% | Unknown significance; reported in COSMIC |
| Promoter hypermethylation | Epigenetic | Frequent in colorectal cancer | Transcriptional silencing; loss of tumor suppressor function |
Mutation functional classification
Loss of Function (LOF)
Promoter hypermethylation and rare missense variants (e.g., p.Met1?) reduce or abolish SFRP2 expression or function, leading to unchecked Wnt signaling.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in SFRP2.
Dominant Negative (DN)
No evidence of dominant-negative mutations in SFRP2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Regulation of Wnt-mediated beta-catenin signaling (Reactome: R-HSA-4641262)
• Signaling by WNT (Reactome: R-HSA-195721)
Protein Summary
SFRP2 is a 295-amino-acid secreted protein containing a signal peptide and a cysteine-rich domain (CRD) that binds Wnt ligands. It acts as a decoy receptor, preventing Wnt from interacting with frizzled receptors and thereby inhibiting both canonical (β-catenin-dependent) and non-canonical Wnt signaling. The protein is involved in developmental processes, tissue remodeling, and is frequently epigenetically silenced in cancers, where its loss contributes to tumor progression. SFRP2 also promotes fibrosis in lung and kidney tissues through alternative Wnt pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SFRP2 Knockout HEK293 Cell Line | EDJ-KQ117 | Human | 6423 | Details Get a Quote |
| SFRP2 Knockout HeLa Cell Line | EDJ-KQ54447 | Human | 6423 | Details Get a Quote |
| SFRP2 Knockout A-549 Cell Line | EDJ-KQ62937 | Human | 6423 | Details Get a Quote |
| SFRP2 Knockout HCT 116 Cell Line | EDJ-KQ71407 | Human | 6423 | Details Get a Quote |
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