SFN (Stratifin) Gene
14-3-3 Protein Sigma: A Key Regulator in Cell Cycle and Cancer
Gene Information Card
| Symbol | SFN |
|---|---|
| Full Name | Stratifin |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.11 |
| NCBI Gene ID | 2810 ncbi.nlm.nih.gov/gene/2810 |
| Ensembl ID | ENSG00000175793 |
| UniProt ID | P31947 |
| OMIM ID | 601290 |
| HGNC ID | 10773 |
| Aliases | 14-3-3 sigma, HME1, YWHAS |
Description
The SFN gene encodes stratifin, a member of the 14-3-3 family of proteins. Stratifin (14-3-3 sigma) is a cell cycle regulator that binds to and inhibits CDC25 phosphatases, leading to G2/M arrest. It also plays roles in DNA damage response, apoptosis, and cell adhesion. SFN is frequently silenced by hypermethylation in various cancers, acting as a tumor suppressor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Loss of SFN expression via promoter hypermethylation contributes to tumor progression and poor prognosis. | PMID: 10655551, COSMIC |
| Lung Cancer | SFN downregulation is associated with increased proliferation and metastasis. | PMID: 15173019, COSMIC |
| Gastric Cancer | SFN methylation is a frequent event and correlates with advanced stage. | PMID: 16189554, ClinVar |
| Prostate Cancer | Reduced SFN expression promotes androgen-independent growth. | PMID: 16951256, COSMIC |
| Bladder Cancer | SFN hypermethylation is linked to invasive phenotype. | PMID: 15510170, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Lung | 6.1 | Low |
| Stomach | 4.7 | Low |
| Prostate | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | Moderate expression |
| A549 (lung cancer) | 3.8 | Low expression |
| HeLa (cervical cancer) | 9.1 | Medium expression |
| HCT116 (colon cancer) | 7.4 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Loss of start codon, likely loss of function |
| c.94C>T (p.Arg32Cys) | missense | <0.1% | Unknown significance |
| c.205G>A (p.Glu69Lys) | missense | <0.1% | Unknown significance |
| c.373C>T (p.Arg125Trp) | missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Promoter hypermethylation leading to transcriptional silencing is the primary loss-of-function mechanism in cancer.
Gain of Function (GOF)
No recurrent gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle
• G2/M DNA damage checkpoint
• 14-3-3-mediated signaling
• p53-dependent G1/S DNA damage checkpoint
Protein Summary
Stratifin (14-3-3 sigma) is a 248-amino acid protein that functions as a homodimeric adapter. It binds phosphorylated serine/threonine residues on target proteins, modulating their activity, localization, and stability. Key targets include CDC25B, CDC25C, CDKN1A (p21), and BAX. Stratifin is essential for G2/M arrest after DNA damage and is a downstream effector of p53. Loss of SFN expression is a common event in epithelial cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SFN Knockout HEK293 Cell Line | EDJ-KQ3405 | Human | 2810 | Details Get a Quote |
| SFN Knockout A-549 Cell Line | EDJ-KQ25109 | Human | 2810 | Details Get a Quote |
| SFN Knockout HCT 116 Cell Line | EDJ-KQ25110 | Human | 2810 | Details Get a Quote |
| SFN Knockout HeLa Cell Line | EDJ-KQ25111 | Human | 2810 | Details Get a Quote |
