SERPINA12
Serpin Family A Member 12 (Vaspin)
Gene Information Card
| Symbol | SERPINA12 |
|---|---|
| Full Name | Serpin Family A Member 12 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 145264 ncbi.nlm.nih.gov/gene/145264 |
| Ensembl ID | ENSG00000165953 |
| UniProt ID | Q8IW75 |
| OMIM ID | 611241 |
| HGNC ID | HGNC:18351 |
| Aliases | Vaspin, OL-64, serpin A12 |
Description
SERPINA12 encodes vaspin (visceral adipose tissue-derived serpin), a member of the serine protease inhibitor (serpin) family. Vaspin is predominantly expressed in visceral adipose tissue and acts as an insulin-sensitizing adipokine. It inhibits specific serine proteases (e.g., kallikrein 7) and is implicated in metabolic disorders such as obesity, type 2 diabetes, and insulin resistance. SERPINA12 expression is regulated by metabolic status and may serve as a biomarker for metabolic syndrome.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered vaspin levels correlate with visceral fat accumulation; potential compensatory mechanism to improve insulin sensitivity | PMID: 15833943 |
| Type 2 Diabetes | Vaspin improves insulin sensitivity and glucose tolerance; reduced levels associated with disease progression | PMID: 15833943 |
| Insulin Resistance | Vaspin inhibits kallikrein 7, reducing inflammation and improving insulin signaling in adipose tissue | PMID: 20876729 |
| Metabolic Syndrome | Elevated serum vaspin linked to dyslipidemia and hypertension; potential biomarker | PMID: 20086238 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose Tissue (Visceral) | 22.5 | Medium |
| Adipose Tissue (Subcutaneous) | 15.3 | Medium |
| Liver | 1.2 | Low |
| Pancreas | 0.8 | Low |
| Skeletal Muscle | 0.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Adipocytes (differentiated) | 18.0 | Primary human adipocytes |
| 3T3-L1 (mouse adipocyte) | 12.5 | Mouse cell line |
| HepG2 | 0.3 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.223G>A (p.Val75Ile) | Missense | <0.01% | Unknown functional effect |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Potential loss of inhibitory activity |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair protease inhibition, reducing insulin-sensitizing effects.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • protease binding |
| • extracellular space | • response to insulin |
| • negative regulation of endopeptidase activity |
Pathways
• Insulin signaling pathway
• Adipocytokine signaling pathway
Protein Summary
Vaspin is a 45-50 kDa secreted glycoprotein belonging to the serpin family. It adopts a conserved serpin fold with a reactive center loop that inhibits target proteases such as kallikrein 7. Vaspin binding to its receptor (yet unidentified) activates intracellular signaling pathways (e.g., PI3K/Akt) that enhance insulin sensitivity and reduce inflammation. Its expression is upregulated in obesity as a compensatory mechanism to counteract metabolic stress.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERPINA12 Knockout HEK293 Cell Line | EDJ-KQ10434 | Human | 145264 | Details Get a Quote |
| SERPINA12 Knockout HeLa Cell Line | EDJ-KQ58518 | Human | 145264 | Details Get a Quote |
| SERPINA12 Knockout A-549 Cell Line | EDJ-KQ67007 | Human | 145264 | Details Get a Quote |
| SERPINA12 Knockout HCT 116 Cell Line | EDJ-KQ75408 | Human | 145264 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
