SERPINA11
Serpin Family A Member 11
Gene Information Card
| Symbol | SERPINA11 |
|---|---|
| Full Name | Serpin Family A Member 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 144501 ncbi.nlm.nih.gov/gene/144501 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q86U17 |
| OMIM ID | 616258 |
| HGNC ID | HGNC:13803 |
| Aliases | SERPINA11, serpin A11, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 |
Description
SERPINA11 is a member of the serpin family of serine protease inhibitors. It is located on chromosome 14q32.13 and encodes a protein of unknown function. The gene is expressed in various tissues, including liver and testis, but its physiological role remains to be fully elucidated.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations confirmed | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.1 | Low |
| Testis | 1.5 | Low |
| Kidney | 0.8 | Not detected |
| Brain | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 1.2 | Low expression |
| HEK293 | 0.5 | Very low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • extracellular region |
Pathways
• No known pathways
Protein Summary
SERPINA11 encodes a 45.5 kDa protein belonging to the serpin family. The protein is predicted to function as a serine protease inhibitor, but its specific target and biological role are not yet characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERPINA11 Knockout HEK293 Cell Line | EDJ-KQ11833 | Human | 256394 | Details Get a Quote |
| SERPINA11 Knockout HeLa Cell Line | EDJ-KQ59303 | Human | 256394 | Details Get a Quote |
| SERPINA11 Knockout A-549 Cell Line | EDJ-KQ67770 | Human | 256394 | Details Get a Quote |
| SERPINA11 Knockout HCT 116 Cell Line | EDJ-KQ76154 | Human | 256394 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
