SERBP1: SERPINE1 mRNA Binding Protein 1
A multifunctional RNA-binding protein involved in mRNA stability, translational regulation, and cellular stress responses.
Gene Information Card
| Symbol | SERBP1 |
|---|---|
| Full Name | SERPINE1 mRNA Binding Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p31.1 |
| NCBI Gene ID | 26135 ncbi.nlm.nih.gov/gene/26135 |
| Ensembl ID | ENSG00000142864 |
| UniProt ID | Q8NC51 |
| OMIM ID | 608872 |
| HGNC ID | 17860 |
| Aliases | PAI-RBP1, CHD3IP, CGI-55, HABP4L, MGC9451 |
Description
SERBP1 encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. The protein binds to the 3' untranslated region (UTR) of SERPINE1 (PAI-1) mRNA, regulating its stability and translation. It is involved in diverse cellular processes including mRNA transport, stress granule formation, and cell cycle control. SERBP1 is ubiquitously expressed and has been implicated in cancer, neurodegenerative diseases, and viral replication.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | SERBP1 overexpression promotes tumor cell proliferation and invasion by stabilizing oncogenic mRNAs; loss of function may impair stress granule assembly. | COSMIC; NCBI Gene; PubMed |
| Alzheimer's disease | SERBP1 interacts with tau protein and may influence tau aggregation and neurodegeneration. | UniProt; PubMed |
| Viral infection (e.g., HIV-1) | SERBP1 binds viral RNA and modulates viral replication. | NCBI Gene; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 23.5 | High |
| Brain (cerebellum) | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Liver | 10.1 | Medium |
| Heart | 8.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.3 | Cervical cancer cell line; high expression |
| HEK293 | 14.7 | Embryonic kidney; moderate expression |
| SH-SY5Y | 12.1 | Neuroblastoma; moderate expression |
| MCF7 | 9.8 | Breast cancer; low-moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown; reported in ClinVar as variant of uncertain significance |
| c.1012G>A (p.Gly338Arg) | Missense | <0.01% | Unknown; reported in ClinVar |
| c.1234_1235insA | Frameshift | <0.01% | Predicted loss of function; not validated in population databases |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations that truncate the protein are predicted to cause loss of RNA-binding function, potentially impairing mRNA regulation and stress granule dynamics.
Gain of Function (GOF)
No well-characterized gain-of-function mutations have been reported for SERBP1.
Dominant Negative (DN)
No evidence for dominant-negative effects; SERBP1 is not known to form obligate dimers.
View complete mutation data：
Gene Ontology (GO)
Pathways
• mRNA surveillance pathway (Reactome: R-HSA-72163)
• Regulation of mRNA stability by proteins that bind AU-rich elements (Reactome: R-HSA-450531)
• Stress granule formation (Reactome: R-HSA-9634638)
Protein Summary
SERBP1 is a 45 kDa RNA-binding protein containing two RNA recognition motifs (RRMs). It shuttles between the nucleus and cytoplasm, binding to the 3' UTR of target mRNAs such as SERPINE1. The protein is a component of stress granules and modulates mRNA stability and translation in response to cellular stress. SERBP1 also interacts with chromatin remodeling factors (e.g., CHD3) and has been linked to tumor progression and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERBP1 Knockout HEK293 Cell Line | EDJ-KQ7750 | Human | 26135 | Details Get a Quote |
| SERBP1 Knockout A-549 Cell Line | EDJ-KQ34523 | Human | 26135 | Details Get a Quote |
| SERBP1 Knockout HCT 116 Cell Line | EDJ-KQ34524 | Human | 26135 | Details Get a Quote |
| SERBP1 Knockout HeLa Cell Line | EDJ-KQ34525 | Human | 26135 | Details Get a Quote |
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