SENP3 (SUMO Specific Peptidase 3)
A key regulator of SUMOylation involved in cellular stress responses and cancer progression.
Gene Information Card
| Symbol | SENP3 |
|---|---|
| Full Name | SUMO specific peptidase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 26168 ncbi.nlm.nih.gov/gene/26168 |
| Ensembl ID | ENSG00000161956 |
| UniProt ID | Q9H4L4 |
| OMIM ID | 612844 |
| HGNC ID | 17827 |
| Aliases | SMT3IP1, SENP3, SUMO1/sentrin specific peptidase 3 |
Description
SENP3 (SUMO specific peptidase 3) encodes a cysteine protease that specifically deconjugates SUMO2 and SUMO3 from target proteins. It plays a critical role in regulating SUMOylation dynamics, particularly under stress conditions such as hypoxia and oxidative stress. SENP3 is involved in cell cycle progression, ribosome biogenesis, and DNA damage repair. Dysregulation of SENP3 has been implicated in various cancers and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression of SENP3 promotes cell proliferation and invasion by deSUMOylating key oncoproteins (e.g., HIF-1α, p53). | COSMIC, PubMed |
| Neurodegenerative diseases | Altered SENP3 activity affects SUMOylation of proteins involved in neuronal survival and aggregation (e.g., tau, α-synuclein). | PubMed |
| Cardiovascular disease | SENP3 modulates cardiac hypertrophy and fibrosis through deSUMOylation of transcription factors. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Bone marrow | 8.5 | Medium |
| Brain | 6.3 | Low |
| Liver | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical cancer cell line |
| HEK293 | 12.1 | Embryonic kidney cell line |
| K562 | 11.4 | Leukemia cell line |
| MCF7 | 9.2 | Breast cancer cell line |
| HepG2 | 7.8 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown; predicted damaging by SIFT |
| c.1246G>A (p.Gly416Arg) | Missense | <0.01% | Unknown; predicted benign |
| c.1489_1490insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1489_1490insA) lead to truncated protein and loss of catalytic activity.
Gain of Function (GOF)
Not well characterized; overexpression in tumors suggests potential gain-of-function effects.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SUMOylation pathway
• Cellular response to hypoxia
• p53 signaling pathway
• Ribosome biogenesis
Protein Summary
SENP3 is a 574-amino acid cysteine protease localized primarily in the nucleolus. It contains a conserved C-terminal catalytic domain (peptidase C48 family) and an N-terminal regulatory region. The enzyme specifically removes SUMO2/SUMO3 modifications from target proteins, thereby reversing SUMOylation. Under stress conditions, SENP3 relocalizes to the nucleoplasm and deSUMOylates substrates such as HIF-1α, p53, and PML, influencing transcription, apoptosis, and cell cycle control. Its overexpression in tumors suggests a role in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SENP3 Knockout HEK293 Cell Line | EDJ-KQ1000 | Human | 26168 | Details Get a Quote |
| SENP3 Knockout A-549 Cell Line | EDJ-KQ20043 | Human | 26168 | Details Get a Quote |
| SENP3 Knockout HCT 116 Cell Line | EDJ-KQ20044 | Human | 26168 | Details Get a Quote |
| SENP3 Knockout HeLa Cell Line | EDJ-KQ18725 | Human | 26168 | Details Get a Quote |
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