SEMG1 (Semenogelin 1)
Key protein in semen coagulation and liquefaction; potential biomarker in male infertility and prostate cancer
Gene Information Card
| Symbol | SEMG1 |
|---|---|
| Full Name | Semenogelin 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 6406 ncbi.nlm.nih.gov/gene/6406 |
| Ensembl ID | ENSG00000124299 |
| UniProt ID | P04279 |
| OMIM ID | 182140 |
| HGNC ID | 10738 |
| Aliases | SGI, SEMG, semenogelin I |
Description
SEMG1 encodes semenogelin 1, the predominant protein in human semen. It is secreted by the seminal vesicles and forms a coagulum that entraps spermatozoa. Subsequent proteolysis by prostate-specific antigen (PSA) liquefies the semen, releasing motile sperm. SEMG1 also exhibits antimicrobial activity and is implicated in male infertility and prostate cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Reduced or absent SEMG1 expression impairs semen coagulation and sperm motility | ClinVar, PubMed |
| Prostate cancer | Altered SEMG1 expression and proteolysis by PSA may influence tumor progression | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Seminal vesicle | >1000 | High |
| Prostate | <10 | Low |
| Testis | <5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | <1 | Very low expression |
| PC-3 (prostate cancer) | <1 | Very low expression |
| DU145 (prostate cancer) | <1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.197C>T (p.Pro66Leu) | Missense | <0.01% | Unknown functional impact |
| c.424G>A (p.Val142Met) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • extracellular space (GO:0005615) |
| • secretory granule (GO:0030141) | • fibrinolysis (GO:0042730) |
| • single fertilization (GO:0007338) | • vasoconstriction (GO:0042310) |
Pathways
• Semen coagulation and liquefaction (Reactome: R-HSA-1474228)
Protein Summary
Semenogelin 1 is a 462-amino acid protein secreted by seminal vesicles. It forms a gel matrix that traps spermatozoa. Cleavage by PSA (kallikrein-3) at specific tyrosine residues leads to semen liquefaction. The protein also contains fibronectin type II domains and has antimicrobial properties.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SEMG1 Knockout HEK293 Cell Line | EDJ-KQ5735 | Human | 6406 | Details Get a Quote |
| SEMG1 Knockout HeLa Cell Line | EDJ-KQ54442 | Human | 6406 | Details Get a Quote |
| SEMG1 Knockout A-549 Cell Line | EDJ-KQ62933 | Human | 6406 | Details Get a Quote |
| SEMG1 Knockout HCT 116 Cell Line | EDJ-KQ71402 | Human | 6406 | Details Get a Quote |
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