SELENOT (Selenoprotein T)
A thioredoxin-like selenoprotein involved in redox regulation, calcium homeostasis, and neuroendocrine function.
Gene Information Card
| Symbol | SELENOT |
|---|---|
| Full Name | Selenoprotein T |
| Gene Type | protein-coding |
| Chromosomal Location | 3q24 |
| NCBI Gene ID | 51714 ncbi.nlm.nih.gov/gene/51714 |
| Ensembl ID | ENSG00000174738 |
| UniProt ID | P62341 |
| OMIM ID | 607215 |
| HGNC ID | 30378 |
| Aliases | SELT, SELT1, SELT2 |
Description
SELENOT encodes selenoprotein T, a thioredoxin-like selenoprotein containing a selenocysteine (Sec) residue at its active site. It is involved in redox homeostasis, calcium mobilization from intracellular stores, and regulation of neuroendocrine secretion. The protein is widely expressed, with highest levels in brain, endocrine tissues, and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors | Overexpression of SELENOT may promote tumor cell survival via redox modulation and calcium signaling. | PMID: 21804563 |
| Alzheimer's disease | Dysregulation of SELENOT expression observed in affected brain regions; potential role in oxidative stress and calcium dyshomeostasis. | PMID: 31505173 |
| Type 2 diabetes | SELENOT variants associated with altered insulin secretion and glucose metabolism in GWAS studies. | PMID: 24509480 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Testis | 10.8 | High |
| Pituitary | 9.2 | High |
| Heart | 4.3 | Medium |
| Liver | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.3 | High expression; used in calcium signaling studies |
| HeLa (cervical carcinoma) | 8.7 | Moderate expression |
| HEK293 (embryonic kidney) | 6.4 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.95G>A (p.Arg32His) | Missense | 0.001% (gnomAD) | Reduced selenocysteine incorporation efficiency |
| c.187C>T (p.Pro63Ser) | Missense | 0.002% (gnomAD) | Altered protein stability |
Mutation functional classification
Loss of Function (LOF)
Loss of selenocysteine insertion or catalytic activity impairs redox regulation and calcium signaling.
Gain of Function (GOF)
Not well documented; overexpression in tumors may confer survival advantage.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Thioredoxin pathway (Reactome: R-HSA-8866423)
• Calcium signaling pathway (KEGG: hsa04020)
Protein Summary
Selenoprotein T is a 182-amino acid thioredoxin-like protein with a conserved CXXU motif (Cys-X-X-Sec) at the active site. It localizes to the endoplasmic reticulum and Golgi apparatus, where it participates in redox regulation and calcium homeostasis. The protein is essential for normal neuroendocrine function and is implicated in cancer and metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENOT Knockout HEK293 Cell Line | EDJ-KQ11201 | Human | 51714 | Details Get a Quote |
| SELENOT Knockout A-549 Cell Line | EDJ-KQ39264 | Human | 51714 | Details Get a Quote |
| SELENOT Knockout HCT 116 Cell Line | EDJ-KQ39265 | Human | 51714 | Details Get a Quote |
| SELENOT Knockout HeLa Cell Line | EDJ-KQ39266 | Human | 51714 | Details Get a Quote |
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