SELENOF: Selenoprotein F (Sep15) - Gene Information and Function
Comprehensive biomedical overview of SELENOF, a selenoprotein involved in redox regulation and protein folding in the endoplasmic reticulum.
Gene Information Card
| Symbol | SELENOF |
|---|---|
| Full Name | Selenoprotein F |
| Gene Type | protein-coding |
| Chromosomal Location | 1p22.3 |
| NCBI Gene ID | 6415 ncbi.nlm.nih.gov/gene/6415 |
| Ensembl ID | ENSG00000162433 |
| UniProt ID | O60613 |
| OMIM ID | 601291 |
| HGNC ID | 10712 |
| Aliases | SELENOF, Sep15, 15 kDa selenoprotein |
Description
SELENOF (selenoprotein F, also known as Sep15) encodes a selenoprotein containing a selenocysteine residue. It is localized in the endoplasmic reticulum (ER) and functions as a thiol-disulfide oxidoreductase involved in redox regulation, protein folding, and protection against oxidative stress. SELENOF is highly expressed in the prostate, thyroid, and liver, and its expression is regulated by selenium levels. Polymorphisms and altered expression have been associated with cancer risk and progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Reduced SELENOF expression may impair antioxidant defense, promoting oxidative damage and tumorigenesis. | PMID: 15642720; COSMIC |
| Breast cancer | Loss of SELENOF expression correlates with poor prognosis; potential tumor suppressor role. | PMID: 19177216; ClinVar |
| Colorectal cancer | SELENOF polymorphisms (e.g., rs5845) associated with increased risk. | PMID: 16951129; NCBI Gene |
| Thyroid cancer | SELENOF downregulation observed in thyroid tumors; linked to altered redox balance. | PMID: 20068074; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Thyroid | 10.8 | Medium |
| Liver | 8.2 | Medium |
| Kidney | 6.4 | Low |
| Lung | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 8.9 | Androgen-independent line |
| MCF-7 (breast cancer) | 7.2 | ER-positive line |
| HepG2 (liver cancer) | 6.5 | Hepatocellular carcinoma |
| HEK293 (embryonic kidney) | 5.0 | Normal transformed line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | rs5845; associated with altered selenium metabolism |
| c.200C>T (p.Thr67Met) | Missense | <0.01% | Reported in COSMIC; functional impact unknown |
| c.311G>A (p.Arg104Gln) | Missense | <0.01% | ClinVar; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Gly38Arg) may reduce selenoprotein stability or redox activity, leading to impaired ER stress response.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein disulfide isomerase activity (GO:0003756) | • endoplasmic reticulum (GO:0005783) |
| • protein folding (GO:0006457) | • protein transport (GO:0015031) |
| • cell redox homeostasis (GO:0045454) |
Pathways
• Endoplasmic reticulum protein processing (KEGG: hsa04141)
• Selenocysteine synthesis and incorporation (Reactome: R-HSA-2408522)
Protein Summary
SELENOF is a 15 kDa selenoprotein localized to the endoplasmic reticulum lumen. It contains a thioredoxin-like fold and a selenocysteine residue at its active site, enabling redox activity. The protein participates in disulfide bond formation and isomerization during protein folding, and protects cells from ER stress-induced apoptosis. SELENOF expression is selenium-dependent and tissue-specific, with highest levels in prostate, thyroid, and liver.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENOF Knockout HEK293 Cell Line | EDJ-KQ6575 | Human | 9403 | Details Get a Quote |
| SELENOF Knockout A-549 Cell Line | EDJ-KQ30788 | Human | 9403 | Details Get a Quote |
| SELENOF Knockout HCT 116 Cell Line | EDJ-KQ30789 | Human | 9403 | Details Get a Quote |
| SELENOF Knockout HeLa Cell Line | EDJ-KQ30790 | Human | 9403 | Details Get a Quote |
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