SCRIB Gene: Scribble Planar Cell Polarity Protein
A scaffold protein involved in cell polarity, proliferation, and tumor suppression.
Gene Information Card
| Symbol | SCRIB |
|---|---|
| Full Name | Scribble Planar Cell Polarity Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.3 |
| NCBI Gene ID | 23513 ncbi.nlm.nih.gov/gene/23513 |
| Ensembl ID | ENSG00000180900 |
| UniProt ID | Q14160 |
| OMIM ID | 607733 |
| HGNC ID | 30377 |
| Aliases | LAP4, SCRIB1, Vartul, CRIB, LAD1, hScrib |
Description
SCRIB encodes a scaffold protein belonging to the LAP (leucine-rich repeats and PDZ domains) family. It is a core component of the Scribble polarity complex, essential for establishing and maintaining epithelial cell polarity, regulating cell proliferation, and suppressing tumor formation. SCRIB interacts with multiple signaling pathways including Wnt, Hippo, and MAPK, and its loss or mislocalization is associated with cancer progression and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neural tube defects | Disruption of planar cell polarity signaling | OMIM: 607733; PMID: 22939625 |
| Colorectal cancer | Loss of SCRIB expression leads to increased Wnt/β-catenin signaling and cell proliferation | COSMIC; PMID: 20010870 |
| Breast cancer | Mislocalization of SCRIB promotes oncogenic signaling and invasion | PMID: 18632637 |
| Prostate cancer | Reduced SCRIB expression correlates with poor prognosis and metastasis | PMID: 21725362 |
| Lung cancer | SCRIB downregulation associated with epithelial-mesenchymal transition | PMID: 23382210 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 14.2 | Medium |
| Lung | 9.8 | Low |
| Liver | 6.1 | Low |
| Kidney | 11.5 | Medium |
| Breast | 10.3 | Medium |
| Colon | 12.7 | Medium |
| Prostate | 8.9 | Low |
| Skin | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical cancer cell line |
| A549 | 12.1 | Lung cancer cell line |
| MCF7 | 11.8 | Breast cancer cell line |
| HCT116 | 14.0 | Colorectal cancer cell line |
| HEK293 | 13.5 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.3592C>T (p.Arg1198*) | Nonsense | <0.1% | Loss of function; truncation of PDZ domains |
| c.1234G>A (p.Gly412Arg) | Missense | <0.1% | Unknown; located in LRR region |
| c.2041_2042insA (p.Thr681Asnfs*2) | Frameshift | <0.1% | Loss of function; premature stop |
| c.2780A>G (p.Asn927Ser) | Missense | <0.1% | Unknown; located in PDZ1 domain |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations that truncate the protein, disrupting PDZ domains and scaffold function, leading to loss of cell polarity and tumor suppression.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in SCRIB.
Dominant Negative (DN)
Missense mutations in PDZ domains may act in a dominant-negative manner by interfering with wild-type SCRIB localization and function, though evidence is limited.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• Wnt signaling pathway (KEGG: hsa04310)
• Tight junction (KEGG: hsa04530)
• Planar cell polarity pathway (Reactome: R-HSA-4086400)
Protein Summary
SCRIB encodes a 1630-amino acid scaffold protein with 16 leucine-rich repeats (LRRs) and 4 PDZ domains. It localizes to the basolateral membrane of epithelial cells and functions as a molecular scaffold to organize signaling complexes at cell junctions. SCRIB regulates cell polarity, proliferation, and migration through interactions with proteins such as β-catenin, PTEN, and LATS1/2. Loss of SCRIB expression or mislocalization is frequently observed in various cancers and correlates with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCRIB Knockout HEK293 Cell Line | EDJ-KQ1385 | Human | 23513 | Details Get a Quote |
| SCRIB Knockout A-549 Cell Line | EDJ-KQ20896 | Human | 23513 | Details Get a Quote |
| SCRIB Knockout HCT 116 Cell Line | EDJ-KQ20897 | Human | 23513 | Details Get a Quote |
| SCRIB Knockout HeLa Cell Line | EDJ-KQ20898 | Human | 23513 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
