SCRG1: Scrapie Responsive Gene 1
A gene encoding a secreted protein implicated in cellular stress responses and potential roles in neurodegenerative and neoplastic processes.
Gene Information Card
| Symbol | SCRG1 |
|---|---|
| Full Name | Scrapie Responsive Gene 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q34.1 |
| NCBI Gene ID | 11341 ncbi.nlm.nih.gov/gene/11341 |
| Ensembl ID | ENSG00000164122 |
| UniProt ID | O75711 |
| OMIM ID | 607489 |
| HGNC ID | 10574 |
| Aliases | SCRG, UNQ307/PRO350 |
Description
SCRG1 (Scrapie Responsive Gene 1) is a protein-coding gene located on chromosome 4q34.1. It encodes a secreted protein of unknown function, but expression studies suggest roles in cellular stress responses, particularly in the context of prion diseases (scrapie) and certain cancers. The gene is upregulated in response to scrapie infection in mice and has been observed to be differentially expressed in various tumor types.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prion disease (scrapie) | Upregulation of SCRG1 in response to prion infection; potential role in neuropathology. | NCBI Gene, OMIM |
| Glioblastoma | Overexpression in glioblastoma cell lines and tissues; may contribute to tumor progression. | COSMIC, PubMed |
| Prostate cancer | Differential expression observed; potential biomarker. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.3 | Low |
| Testis | 0.1 | Low |
| Prostate | 0.2 | Low |
| Lung | 0.1 | Low |
| Kidney | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U-87 MG (glioblastoma) | 0.5 | Overexpressed relative to normal brain |
| PC-3 (prostate cancer) | 0.3 | Moderate expression |
| HEK293 (embryonic kidney) | 0.1 | Low baseline expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; effect unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Rare variant; no known functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • protein binding |
| • cellular response to stress |
Pathways
• Prion disease pathway (KEGG)
Protein Summary
SCRG1 encodes a 98-amino acid secreted protein with a signal peptide. The mature protein is predicted to be involved in intercellular signaling, particularly under stress conditions. Its exact biochemical function remains unclear, but it is hypothesized to modulate cellular responses to prion infection and may influence tumor cell behavior.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCRG1 Knockout HEK293 Cell Line | EDJ-KQ6736 | Human | 11341 | Details Get a Quote |
| SCRG1 Knockout HeLa Cell Line | EDJ-KQ55635 | Human | 11341 | Details Get a Quote |
| SCRG1 Knockout A-549 Cell Line | EDJ-KQ64133 | Human | 11341 | Details Get a Quote |
| SCRG1 Knockout HCT 116 Cell Line | EDJ-KQ72578 | Human | 11341 | Details Get a Quote |
