SCLY (Selenocysteine Lyase)
Gene encoding the enzyme responsible for selenocysteine decomposition and selenium recycling
Gene Information Card
| Symbol | SCLY |
|---|---|
| Full Name | Selenocysteine Lyase |
| Gene Type | Protein coding |
| Chromosomal Location | 2q37.3 |
| NCBI Gene ID | 51540 ncbi.nlm.nih.gov/gene/51540 |
| Ensembl ID | ENSG00000163082 |
| UniProt ID | Q96I15 |
| OMIM ID | 613958 |
| HGNC ID | HGNC:24384 |
| Aliases | SECp43, SCL |
Description
SCLY encodes selenocysteine lyase, a pyridoxal phosphate-dependent enzyme that catalyzes the decomposition of selenocysteine to L-alanine and elemental selenium. This reaction is essential for selenium recycling and the biosynthesis of selenoproteins, which play critical roles in antioxidant defense, thyroid hormone metabolism, and redox regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Selenium deficiency | Impaired selenium recycling due to SCLY dysfunction leads to reduced selenoprotein synthesis | PMID: 19056867 |
| Cancer (colorectal, prostate) | Altered SCLY expression may affect selenium-dependent antioxidant capacity and tumor progression | PMID: 23431279 |
| Neurodegenerative disorders | Selenium dysregulation via SCLY variants may contribute to oxidative stress in neurons | PMID: 25687213 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 9.8 | Medium |
| Testis | 7.3 | Low |
| Brain | 4.1 | Low |
| Heart | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 11.2 | Hepatocellular carcinoma cell line |
| HEK293 | 8.6 | Embryonic kidney cells |
| MCF7 | 5.4 | Breast cancer cell line |
| PC3 | 4.9 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | <0.01% | Reduced enzyme activity in vitro |
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Impaired substrate binding |
| c.832delC | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and missense mutations (e.g., p.Pro35Leu, p.Gly163Arg) reduce or abolish selenocysteine lyase activity, impairing selenium recycling.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • selenocysteine lyase activity (GO:0009000) | • pyridoxal phosphate binding (GO:0030170) |
| • cytoplasm (GO:0005737) | • selenocysteine catabolic process (GO:0019346) |
| • cell redox homeostasis (GO:0045454) |
Pathways
• Selenium metabolism (Reactome: R-HSA-2408522)
• Selenoamino acid metabolism (KEGG: hsa00450)
Protein Summary
Selenocysteine lyase (UniProt Q96I15) is a 432-amino acid homodimeric enzyme localized in the cytoplasm. It uses pyridoxal phosphate as a cofactor to specifically cleave selenocysteine into L-alanine and selenium, which is then used for selenoprotein synthesis. The enzyme is critical for selenium homeostasis and protection against oxidative stress.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCLY Knockout HEK293 Cell Line | EDJ-KQ3034 | Human | 51540 | Details Get a Quote |
| SCLY Knockout HeLa Cell Line | EDJ-KQ22898 | Human | 51540 | Details Get a Quote |
| SCLY Knockout A-549 Cell Line | EDJ-KQ24266 | Human | 51540 | Details Get a Quote |
| SCLY Knockout HCT 116 Cell Line | EDJ-KQ24267 | Human | 51540 | Details Get a Quote |
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