SCGB1D1 (Secretoglobin Family 1D Member 1): A Secreted Lipophilic Ligand Carrier with Potential Roles in Chemosensation and Cancer
Comprehensive genomic, proteomic, and disease association data for SCGB1D1, a member of the secretoglobin family, with expression profiles and mutation analysis.
Gene Information Card
| Symbol | SCGB1D1 |
|---|---|
| Full Name | Secretoglobin family 1D member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 77948 ncbi.nlm.nih.gov/gene/77948 |
| Ensembl ID | ENSG00000167992 |
| UniProt ID | Q8WU39 |
| OMIM ID | 612059 |
| HGNC ID | 18391 |
| Aliases | LYPD2, MGC126852, MGC126854 |
Description
SCGB1D1 encodes a small secreted protein belonging to the secretoglobin family. Secretoglobins are involved in binding and transporting small lipophilic molecules, immunomodulation, and chemosensation. SCGB1D1 is expressed in various tissues, with notable presence in the prostate and respiratory tract. Its exact physiological role is still under investigation, but it may participate in pheromone transport and inflammatory responses. Altered expression has been observed in certain cancers, suggesting a potential biomarker role.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Potential tumor suppressor; reduced expression may correlate with disease progression. | Expression studies (PMID: 21746804) show downregulation in prostate cancer tissues. |
| Breast cancer | Possible involvement in hormone-responsive tumors; expression changes may affect tumor microenvironment. | Gene expression profiling (PMID: 21856715) indicates altered SCGB1D1 levels in breast cancer. |
| Respiratory diseases | Secretoglobins modulate inflammation; SCGB1D1 may play a role in airway defense. | Inferred from family function; direct evidence limited. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.3 | Medium |
| Trachea | 8.5 | Low |
| Lung | 6.2 | Low |
| Testis | 4.1 | Low |
| Kidney | 2.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 15.2 | Moderate expression |
| A549 (lung carcinoma) | 7.8 | Low expression |
| MCF7 (breast cancer) | 3.4 | Very low expression |
| HEK293 (embryonic kidney) | 0.5 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | 0.01% (gnomAD) | Potential disruption of disulfide bond; functional impact unknown. |
| c.45G>A (p.Trp15Ter) | Nonsense | Rare (0.001%) | Likely loss-of-function; may lead to nonsense-mediated decay. |
| c.88A>G (p.Ile30Val) | Missense | 0.05% | Benign; no known effect. |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutation p.Trp15Ter likely results in a truncated protein, leading to loss of function. No known disease association yet.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • protein binding (GO:0005515) |
| • odorant binding (GO:0005549) | • inflammatory response (GO:0006954) |
| • signal transduction (GO:0007165) |
Pathways
• No specific pathway curated in Reactome or KEGG for SCGB1D1. It may participate in steroid hormone signaling and chemosensory pathways.
Protein Summary
SCGB1D1 is a small (about 10 kDa) secreted protein with a characteristic secretoglobin fold, consisting of four alpha-helices. It forms homodimers and can bind small lipophilic ligands such as steroids and pheromones. The protein is glycosylated and localized to the extracellular space. Its expression is highest in prostate and respiratory tissues, suggesting roles in local immune modulation and chemical communication. Structural studies indicate a conserved binding pocket for hydrophobic molecules.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCGB1D1 Knockout HEK293 Cell Line | EDJ-KQ50998 | Human | 10648 | Details Get a Quote |
| SCGB1D1 Knockout HeLa Cell Line | EDJ-KQ55453 | Human | 10648 | Details Get a Quote |
| SCGB1D1 Knockout A-549 Cell Line | EDJ-KQ63935 | Human | 10648 | Details Get a Quote |
| SCGB1D1 Knockout HCT 116 Cell Line | EDJ-KQ72393 | Human | 10648 | Details Get a Quote |
