SCAND1: SCAN Domain-Containing Protein 1
A zinc finger transcription factor involved in cellular proliferation and cancer biology
Gene Information Card
| Symbol | SCAND1 |
|---|---|
| Full Name | SCAN domain-containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 51282 ncbi.nlm.nih.gov/gene/51282 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9H2T7 |
| OMIM ID | 607057 |
| HGNC ID | 10567 |
| Aliases | SDP1, RAZ1, SCAN domain-containing protein 1 |
Description
SCAND1 (SCAN domain-containing 1) encodes a protein that belongs to the SCAN domain family of zinc finger transcription factors. The SCAND1 protein contains a conserved SCAN domain at the N-terminus and a C2H2-type zinc finger motif, enabling DNA binding and transcriptional regulation. It is involved in cell proliferation, differentiation, and has been implicated in various cancers. SCAND1 can form heterodimers with other SCAN domain proteins, modulating their transcriptional activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | SCAND1 overexpression promotes cell proliferation and migration via transcriptional activation of oncogenic targets | PMID: 25605247 |
| Breast cancer | SCAND1 upregulation correlates with poor prognosis and enhanced tumor growth | PMID: 28397838 |
| Colorectal cancer | SCAND1 knockdown reduces cell viability and induces apoptosis in vitro | PMID: 31065024 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 7.1 | Low |
| Prostate | 6.8 | Low |
| Breast | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical cancer cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| LNCaP | 9.8 | Prostate cancer cell line |
| HCT116 | 8.5 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.454G>A (p.Glu152Lys) | Missense | <0.01% | Predicted benign |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) are predicted to abolish protein translation, leading to loss of SCAND1 function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SCAND1.
Dominant Negative (DN)
No evidence for dominant-negative effects in SCAND1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:1989781~Transcriptional regulation by RUNX3
• REACT:212436~Generic Transcription Pathway
Protein Summary
SCAND1 is a 510-amino acid protein with a molecular weight of approximately 56 kDa. It contains an N-terminal SCAN domain (residues 1-70) and a C-terminal C2H2-type zinc finger domain (residues 430-458). The SCAN domain mediates protein-protein interactions, particularly homodimerization and heterodimerization with other SCAN family members, while the zinc finger domain binds to specific DNA sequences to regulate gene expression. SCAND1 is predominantly nuclear and acts as a transcriptional activator. Post-translational modifications include phosphorylation, which may modulate its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAND1 Knockout HEK293 Cell Line | EDJ-KQ51302 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout HeLa Cell Line | EDJ-KQ56268 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout A-549 Cell Line | EDJ-KQ64757 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout HCT 116 Cell Line | EDJ-KQ73204 | Human | 51282 | Details Get a Quote |
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