SCAMP4: Secretory Carrier Membrane Protein 4
A key component in vesicular trafficking and membrane transport
Gene Information Card
| Symbol | SCAMP4 |
|---|---|
| Full Name | Secretory Carrier Membrane Protein 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 113178 ncbi.nlm.nih.gov/gene/113178 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q96GZ6 |
| OMIM ID | 613761 |
| HGNC ID | 30365 |
| Aliases | SCAMP4, SCAMP-4 |
Description
SCAMP4 encodes secretory carrier membrane protein 4, a member of the SCAMP family involved in vesicular trafficking and membrane transport. SCAMP4 is localized to recycling endosomes and the plasma membrane, playing a role in endocytosis and exocytosis. It is ubiquitously expressed with highest levels in the brain, kidney, and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered SCAMP4 expression may affect vesicle-mediated signaling and cell proliferation. | NCBI Gene, COSMIC |
| Neurodegenerative disorders | SCAMP4 involvement in synaptic vesicle recycling suggests potential links to neuronal dysfunction. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Testis | 8.9 | Medium |
| Liver | 6.1 | Low |
| Heart | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression in embryonic kidney cells |
| HeLa | 8.2 | Moderate expression in cervical cancer cells |
| SH-SY5Y | 11.4 | High expression in neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
• Membrane trafficking (Reactome: R-HSA-199991)
Protein Summary
SCAMP4 is a 25 kDa transmembrane protein with four predicted transmembrane domains. It localizes to recycling endosomes and the plasma membrane, where it facilitates vesicle docking and fusion. The protein contains a conserved SCAMP domain and is involved in endocytic recycling and exocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAMP4 Knockout HEK293 Cell Line | EDJ-KQ7410 | Human | 113178 | Details Get a Quote |
| SCAMP4 Knockout A-549 Cell Line | EDJ-KQ32582 | Human | 113178 | Details Get a Quote |
| SCAMP4 Knockout HCT 116 Cell Line | EDJ-KQ32583 | Human | 113178 | Details Get a Quote |
| SCAMP4 Knockout HeLa Cell Line | EDJ-KQ32584 | Human | 113178 | Details Get a Quote |
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