SCAMP3: Secretory Carrier Membrane Protein 3
A key player in vesicular trafficking and endosomal recycling, implicated in cancer and neurodegenerative disorders.
Gene Information Card
| Symbol | SCAMP3 |
|---|---|
| Full Name | Secretory Carrier Membrane Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.2 |
| NCBI Gene ID | 10067 ncbi.nlm.nih.gov/gene/10067 |
| Ensembl ID | ENSG00000116584 |
| UniProt ID | O14828 |
| OMIM ID | 606913 |
| HGNC ID | 10565 |
| Aliases | SCAMP3, C1orf3, SCAMP3_HUMAN |
Description
SCAMP3 encodes a member of the secretory carrier membrane protein family, which functions in vesicular trafficking, endosomal recycling, and exocytosis. The protein is localized to recycling endosomes and the plasma membrane, facilitating the transport of cargo proteins and lipids. SCAMP3 is ubiquitously expressed and has been implicated in cancer progression and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SCAMP3 overexpression promotes tumor cell proliferation and migration via enhanced EGFR recycling. | PMID: 25605274 |
| Alzheimer's disease | SCAMP3 interacts with APP and BACE1, modulating amyloid-beta production. | PMID: 23382691 |
| Glioblastoma | SCAMP3 upregulation correlates with poor prognosis and increased invasiveness. | PMID: 29187725 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 15.2 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | High expression in cervical cancer cells |
| MCF7 | 22.3 | High expression in breast cancer cells |
| HEK293 | 14.1 | Moderate expression |
| SH-SY5Y | 16.5 | High expression in neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.454C>T (p.Arg152Trp) | Missense | 0.005% (gnomAD) | Potential loss of function in vesicle trafficking |
| c.631_633del (p.Phe211del) | In-frame deletion | <0.001% | Altered protein localization |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the cytoplasmic domain may impair endosomal recycling.
Gain of Function (GOF)
Overexpression in cancer cells suggests potential gain-of-function in proliferation.
Dominant Negative (DN)
Truncating mutations could interfere with wild-type SCAMP3 function.
View complete mutation data：
Gene Ontology (GO)
| • vesicle-mediated transport | • endosomal recycling |
| • protein transport | • membrane fusion |
| • exocytosis | • Golgi vesicle transport |
Pathways
• Endosomal recycling pathway
• EGFR signaling
• Vesicle trafficking
Protein Summary
SCAMP3 is a 338-amino acid integral membrane protein with four transmembrane domains, localized primarily to recycling endosomes. It contains a conserved N-terminal cytoplasmic domain that interacts with clathrin and adaptor proteins, regulating cargo sorting. The protein is post-translationally modified by palmitoylation, which is essential for its membrane association and function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAMP3 Knockout HEK293 Cell Line | EDJ-KQ6883 | Human | 10067 | Details Get a Quote |
| SCAMP3 Knockout A-549 Cell Line | EDJ-KQ31479 | Human | 10067 | Details Get a Quote |
| SCAMP3 Knockout HCT 116 Cell Line | EDJ-KQ31480 | Human | 10067 | Details Get a Quote |
| SCAMP3 Knockout HeLa Cell Line | EDJ-KQ31481 | Human | 10067 | Details Get a Quote |
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