SCAMP2: Secretory Carrier Membrane Protein 2
A key player in vesicular trafficking and membrane transport
Gene Information Card
| Symbol | SCAMP2 |
|---|---|
| Full Name | Secretory Carrier Membrane Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q23 |
| NCBI Gene ID | 10066 ncbi.nlm.nih.gov/gene/10066 |
| Ensembl ID | ENSG00000140479 |
| UniProt ID | O15127 |
| OMIM ID | 606912 |
| HGNC ID | 10566 |
| Aliases | SCAMP2, SCAMP-2 |
Description
SCAMP2 (Secretory Carrier Membrane Protein 2) encodes a member of the secretory carrier membrane protein family. The protein is involved in vesicular trafficking, particularly in the recycling of synaptic vesicles and membrane transport between the Golgi apparatus and the plasma membrane. It is widely expressed in various tissues and plays a role in exocytosis and endocytosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM as of 2025 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.0 | Moderate expression |
| HeLa | 11.2 | Moderate expression |
| A549 | 9.5 | Low expression |
| SH-SY5Y | 16.8 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • intracellular protein transport (GO:0006886) | • vesicle-mediated transport (GO:0016192) |
| • Golgi apparatus (GO:0005794) | • membrane (GO:0016020) |
| • protein binding (GO:0005515) |
Pathways
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
• Membrane trafficking (Reactome: R-HSA-199991)
Protein Summary
SCAMP2 is a 338-amino acid protein with four transmembrane domains, localized to secretory vesicles and the plasma membrane. It functions as a carrier in the recycling of synaptic vesicles and is involved in the regulation of exocytosis. The protein interacts with other vesicular trafficking components and is essential for normal neurotransmitter release.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAMP2 Knockout HEK293 Cell Line | EDJ-KQ6245 | Human | 10066 | Details Get a Quote |
| SCAMP2 Knockout A-549 Cell Line | EDJ-KQ31476 | Human | 10066 | Details Get a Quote |
| SCAMP2 Knockout HCT 116 Cell Line | EDJ-KQ31477 | Human | 10066 | Details Get a Quote |
| SCAMP2 Knockout HeLa Cell Line | EDJ-KQ31478 | Human | 10066 | Details Get a Quote |
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