SCAMP1: Secretory Carrier Membrane Protein 1
A key player in vesicular trafficking and membrane transport
Gene Information Card
| Symbol | SCAMP1 |
|---|---|
| Full Name | Secretory Carrier Membrane Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q14.1 |
| NCBI Gene ID | 9522 ncbi.nlm.nih.gov/gene/9522 |
| Ensembl ID | ENSG00000113522 |
| UniProt ID | O15126 |
| OMIM ID | 606911 |
| HGNC ID | 10563 |
| Aliases | SCAMP, SCAMP37 |
Description
SCAMP1 encodes a member of the secretory carrier membrane protein family, which are integral membrane proteins involved in vesicular trafficking and exocytosis. SCAMP1 is ubiquitously expressed and functions in recycling endosomes and post-Golgi transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered SCAMP1 expression may affect vesicle trafficking and cell signaling, contributing to tumor progression. | NCBI Gene, COSMIC |
| Neurodegenerative disorders | Potential role in synaptic vesicle recycling; dysregulation linked to neuronal dysfunction. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Liver | 10.5 | Medium |
| Kidney | 14.1 | Medium |
| Heart | 11.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical cancer cell line |
| HEK293 | 16.2 | Embryonic kidney cells |
| A549 | 14.7 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | 0.01% | p.Arg41Cys; functional impact unknown |
| c.456G>A | Synonymous | 0.02% | No amino acid change |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • intracellular protein transport (GO:0006886) | • vesicle-mediated transport (GO:0016192) |
| • membrane (GO:0016020) | • plasma membrane (GO:0005886) |
Pathways
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
• Membrane trafficking (Reactome: R-HSA-199991)
Protein Summary
SCAMP1 is a 338-amino acid integral membrane protein with four transmembrane domains. It localizes to recycling endosomes and the plasma membrane, facilitating vesicle docking and fusion. It is widely expressed and plays a role in exocytosis and endocytic recycling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAMP1 Knockout HEK293 Cell Line | EDJ-KQ3772 | Human | 9522 | Details Get a Quote |
| SCAMP1 Knockout HCT 116 Cell Line | EDJ-KQ24501 | Human | 9522 | Details Get a Quote |
| SCAMP1 Knockout A-549 Cell Line | EDJ-KQ25862 | Human | 9522 | Details Get a Quote |
| SCAMP1 Knockout HeLa Cell Line | EDJ-KQ25864 | Human | 9522 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
