S1PR5
Sphingosine-1-Phosphate Receptor 5
Gene Information Card
| Symbol | S1PR5 |
|---|---|
| Full Name | sphingosine-1-phosphate receptor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 53637 ncbi.nlm.nih.gov/gene/53637 |
| Ensembl ID | ENSG00000180739 |
| UniProt ID | Q9H228 |
| OMIM ID | 605146 |
| HGNC ID | 15394 |
| Aliases | EDG8, S1P5, SPPR-1, MGC138239 |
Description
S1PR5 (sphingosine-1-phosphate receptor 5) is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors. It binds the bioactive lipid sphingosine-1-phosphate (S1P) with high affinity. S1PR5 is predominantly expressed in the central nervous system, particularly in oligodendrocytes, and in natural killer (NK) cells. It regulates oligodendrocyte survival and process extension, NK cell trafficking, and vascular integrity. The gene is located on chromosome 19p13.2 and encodes a 398-amino acid protein.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multiple sclerosis | S1PR5 modulation by fingolimod (FTY720) affects oligodendrocyte survival and remyelination; altered expression in MS lesions | PMID: 20037579 |
| Natural killer cell deficiency | S1PR5 mutations impair NK cell egress from bone marrow and lymph nodes | PMID: 26951697 |
| Glioblastoma | S1PR5 overexpression promotes tumor cell migration and invasion via S1P signaling | PMID: 23541953 |
| Colorectal cancer | S1PR5 expression correlates with poor prognosis and metastasis | PMID: 29187738 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Spinal cord | 6.5 | Medium |
| Spleen | 4.1 | Low |
| Lung | 3.0 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Oligodendrocytes | 12.5 | High expression |
| NK cells | 9.8 | High expression |
| Astrocytes | 2.1 | Low expression |
| HEK293 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.763C>T (p.Arg255*) | Nonsense | <0.01% | Loss of function; associated with NK cell deficiency |
| c.1000G>A (p.Gly334Ser) | Missense | <0.01% | Reduced S1P binding affinity |
| c.124A>G (p.Thr42Ala) | Missense | 0.02% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutation p.Arg255* leads to truncated protein lacking transmembrane domains, resulting in complete loss of S1P signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • sphingosine-1-phosphate receptor activity |
| • signal transduction | • positive regulation of cell migration |
| • oligodendrocyte differentiation | • natural killer cell chemotaxis |
Pathways
• Sphingosine-1-phosphate signaling pathway
• GPCR downstream signaling
• Lysosphingolipid and LPA receptors
Protein Summary
S1PR5 is a 398-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by sphingosine-1-phosphate, leading to coupling with Gi/o proteins, inhibition of adenylyl cyclase, and activation of MAPK and PI3K pathways. The protein is critical for oligodendrocyte survival and process extension, NK cell egress from lymphoid organs, and regulation of endothelial barrier function. It is a target of the immunomodulatory drug fingolimod (FTY720).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S1PR5 Knockout HEK293 Cell Line | EDJ-KQ1757 | Human | 53637 | Details Get a Quote |
| S1PR5 Knockout HCT 116 Cell Line | EDJ-KQ20287 | Human | 53637 | Details Get a Quote |
| S1PR5 Knockout A-549 Cell Line | EDJ-KQ21634 | Human | 53637 | Details Get a Quote |
| S1PR5 Knockout HeLa Cell Line | EDJ-KQ21636 | Human | 53637 | Details Get a Quote |
| S1PR5 Knockout HAP1 Cell Line | EDC08042 | Human | 53637 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
