S1PR3 (Sphingosine-1-Phosphate Receptor 3)
A G protein-coupled receptor for sphingosine-1-phosphate involved in cardiovascular, immune, and nervous system regulation.
Gene Information Card
| Symbol | S1PR3 |
|---|---|
| Full Name | Sphingosine-1-Phosphate Receptor 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q22.1 |
| NCBI Gene ID | 1903 ncbi.nlm.nih.gov/gene/1903 |
| Ensembl ID | ENSG00000136868 |
| UniProt ID | Q99500 |
| OMIM ID | 601965 |
| HGNC ID | 3165 |
| Aliases | EDG3, LPB3, S1P3 |
Description
S1PR3 (sphingosine-1-phosphate receptor 3) is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors. It binds the bioactive lipid sphingosine-1-phosphate (S1P) and mediates diverse cellular responses including proliferation, migration, cytoskeletal rearrangement, and angiogenesis. S1PR3 is widely expressed and plays critical roles in cardiovascular development, immune cell trafficking, and neural function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cardiovascular diseases (e.g., atherosclerosis, myocardial infarction) | S1PR3 signaling modulates endothelial barrier function, vascular tone, and inflammatory cell recruitment. Altered expression or activity contributes to vascular pathology. | ClinVar, NCBI Gene |
| Cancer (e.g., breast, ovarian, glioma) | S1PR3 promotes tumor cell proliferation, migration, and angiogenesis via S1P-dependent pathways. Overexpression is associated with poor prognosis. | COSMIC, NCBI Gene |
| Multiple sclerosis | S1PR3 on immune cells and glia influences neuroinflammation and demyelination. S1P receptor modulators (e.g., fingolimod) target S1PR3 among others. | NCBI Gene, OMIM |
| Pulmonary fibrosis | S1PR3 activation on fibroblasts and endothelial cells contributes to fibrotic remodeling in lung tissue. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Heart | 9.2 | Medium |
| Brain | 7.1 | Low |
| Liver | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 15.0 | High expression |
| HEK293 | 8.5 | Moderate |
| A549 (lung carcinoma) | 6.2 | Low to moderate |
| U87MG (glioma) | 4.8 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact; rare variant |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Predicted benign; no disease association reported |
| c.784C>T (p.Arg262Cys) | Missense | <0.01% | Likely benign; no known phenotype |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in S1PR3.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in S1PR3.
Dominant Negative (DN)
No dominant-negative mutations described for S1PR3.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • sphingosine-1-phosphate receptor activity |
| • cell surface receptor signaling pathway | • angiogenesis |
| • positive regulation of cell migration | • positive regulation of cytosolic calcium ion concentration |
| • G protein-coupled receptor signaling pathway |
Pathways
• Sphingosine-1-phosphate (S1P) signaling pathway
• GPCR downstream signaling
• Endothelial barrier regulation
• Immune cell trafficking
Protein Summary
S1PR3 is a 378-amino acid integral membrane protein with seven transmembrane domains typical of GPCRs. It couples primarily to Gq and Gi proteins, leading to activation of phospholipase C, calcium mobilization, and MAPK/ERK signaling. The receptor is N-glycosylated and undergoes agonist-induced internalization. S1PR3 is critical for vascular development and immune regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S1PR3 Knockout HEK293 Cell Line | EDJ-KQ1009 | Human | 1903 | Details Get a Quote |
| S1PR3 Knockout A-549 Cell Line | EDJ-KQ20064 | Human | 1903 | Details Get a Quote |
| S1PR3 Knockout HeLa Cell Line | EDJ-KQ20065 | Human | 1903 | Details Get a Quote |
| S1PR3 Knockout HCT 116 Cell Line | EDJ-KQ77854 | Human | 1903 | Details Get a Quote |
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