S1PR2 (Sphingosine-1-Phosphate Receptor 2)
A G protein-coupled receptor involved in immune regulation, vascular development, and cancer biology.
Gene Information Card
| Symbol | S1PR2 |
|---|---|
| Full Name | sphingosine-1-phosphate receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 9294 ncbi.nlm.nih.gov/gene/9294 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | O95136 |
| OMIM ID | 605111 |
| HGNC ID | 3165 |
| Aliases | EDG5, Gpcr13, H218, LPB2, S1P2 |
Description
S1PR2 encodes a G protein-coupled receptor for sphingosine-1-phosphate (S1P), a bioactive lysophospholipid. The receptor is involved in cell migration, proliferation, and cytoskeletal organization. It plays critical roles in immune cell trafficking, vascular development, and auditory function. Dysregulation of S1PR2 signaling is implicated in cancer progression, autoimmune diseases, and hearing loss.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hearing loss (autosomal recessive deafness 108) | Loss-of-function mutations in S1PR2 disrupt S1P signaling in cochlear hair cells, leading to sensorineural hearing loss. | ClinVar; OMIM #616958 |
| Cancer (e.g., hepatocellular carcinoma) | Altered S1PR2 expression modulates tumor cell migration and angiogenesis; may act as a tumor suppressor or promoter depending on context. | COSMIC; PubMed studies |
| Autoimmune diseases (e.g., multiple sclerosis) | S1PR2 regulates lymphocyte egress from lymphoid organs; aberrant signaling contributes to neuroinflammation. | NCBI Gene; literature review |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Heart | 8.7 | Low |
| Lung | 15.2 | Medium |
| Liver | 20.1 | High |
| Spleen | 18.5 | High |
| Kidney | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.5 | Moderate expression |
| HeLa | 11.2 | Moderate expression |
| HepG2 | 22.3 | High expression |
| Jurkat | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.587G>A (p.Arg196His) | Missense | <0.01% | Reduced receptor activity; associated with hearing loss (ClinVar) |
| c.1A>G (p.Met1?) | Start loss | <0.01% | Loss of protein expression; pathogenic in deafness (ClinVar) |
| c.832C>T (p.Arg278*) | Nonsense | <0.01% | Premature truncation; loss of function (ClinVar) |
Mutation functional classification
Loss of Function (LOF)
Missense, nonsense, and start-loss variants that impair S1P binding or receptor activation, leading to reduced downstream signaling (e.g., hearing loss).
Gain of Function (GOF)
Not well-documented; some cancer-associated variants may enhance signaling but require further validation.
Dominant Negative (DN)
Not reported for S1PR2.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • sphingosine-1-phosphate receptor activity (GO:0038034) |
| • cell migration (GO:0016477) | • positive regulation of Rho protein signal transduction (GO:0035025) |
| • angiogenesis (GO:0001525) | • immune system process (GO:0002376) |
Pathways
• Sphingosine-1-phosphate signaling pathway (Reactome: R-HSA-419408)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Rho GTPase cycle (Reactome: R-HSA-194840)
Protein Summary
S1PR2 is a 353-amino acid integral membrane protein with seven transmembrane domains. It couples primarily to Gαi/o and Gα12/13 proteins, activating Rho and inhibiting adenylyl cyclase. The receptor mediates S1P-induced cell contraction, migration, and survival. It is expressed in multiple tissues, with highest levels in liver and spleen. Structural studies reveal a conserved S1P binding pocket critical for ligand recognition.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S1PR2 Knockout HEK293 Cell Line | EDJ-KQ1756 | Human | 9294 | Details Get a Quote |
| S1PR2 Knockout HCT 116 Cell Line | EDJ-KQ21632 | Human | 9294 | Details Get a Quote |
| S1PR2 Knockout HeLa Cell Line | EDJ-KQ21633 | Human | 9294 | Details Get a Quote |
| S1PR2 Knockout A-549 Cell Line | EDJ-KQ63603 | Human | 9294 | Details Get a Quote |
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