S100A10
S100 Calcium Binding Protein A10 (p11)
Gene Information Card
| Symbol | S100A10 |
|---|---|
| Full Name | S100 calcium binding protein A10 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 6281 ncbi.nlm.nih.gov/gene/6281 |
| Ensembl ID | ENSG00000197771 |
| UniProt ID | P60903 |
| OMIM ID | 114085 |
| HGNC ID | 10494 |
| Aliases | p11, ANX2LG, CAL1L, CLP11, GP11, 42C |
Description
S100A10 (p11) is a member of the S100 family of calcium-binding proteins. Unlike most S100 proteins, S100A10 is not calcium-responsive due to mutations in its EF-hand motifs. It functions primarily as a ligand for annexin II, forming a heterotetrameric complex that regulates membrane trafficking, exocytosis, and fibrinolysis. S100A10 is involved in cell proliferation, migration, and invasion, and its dysregulation is linked to cancer and psychiatric disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression of S100A10 promotes tumor cell invasion and metastasis by enhancing plasmin generation via annexin II binding. | ClinVar, COSMIC |
| Major Depressive Disorder | Reduced S100A10 expression in brain regions alters serotonin receptor signaling and synaptic plasticity. | OMIM, NCBI Gene |
| Anxiety Disorders | S100A10 knockout mice exhibit increased anxiety-like behaviors, linked to altered 5-HT1B receptor function. | OMIM, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 28.5 | High |
| Kidney | 22.3 | High |
| Liver | 18.7 | Medium |
| Brain | 15.2 | Medium |
| Heart | 12.1 | Medium |
| Skeletal Muscle | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 35.2 | High expression |
| HEK293 (embryonic kidney) | 25.6 | Moderate expression |
| HepG2 (hepatocellular carcinoma) | 20.1 | Moderate expression |
| SH-SY5Y (neuroblastoma) | 14.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Gly32Arg) | Missense | <0.1% | Unknown functional effect; rare variant |
| c.205C>T (p.Arg69Cys) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
| c.310_311insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, though no confirmed pathogenic variants are documented.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • protein heterodimerization activity |
| • annexin binding | • phospholipase A2 inhibitor activity |
| • cell surface |
Pathways
• Annexin II-mediated plasmin generation
• Fibrinolysis
• Serotonin receptor signaling
Protein Summary
S100A10 (p11) is a 97-amino acid protein that forms a heterotetrameric complex with annexin II. It lacks calcium-binding activity due to critical mutations in its EF-hand domains. The protein is localized to the plasma membrane and endosomal compartments, where it regulates membrane trafficking, exocytosis, and cell surface proteolysis. S100A10 is overexpressed in many cancers and contributes to metastasis. In the brain, it modulates serotonin receptor function and is implicated in mood disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100A10 Knockout HEK293 Cell Line | EDJ-KQ3811 | Human | 6281 | Details Get a Quote |
| S100A10 Knockout A-549 Cell Line | EDJ-KQ25938 | Human | 6281 | Details Get a Quote |
| S100A10 Knockout HCT 116 Cell Line | EDJ-KQ25939 | Human | 6281 | Details Get a Quote |
| S100A10 Knockout HeLa Cell Line | EDJ-KQ25940 | Human | 6281 | Details Get a Quote |
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